The invention relates to exsulins or insulin mimetic amino acid sequences with a molecular weight of up to 55,000 daltons and with 1 to 50 basic units of following Formula (I): [-] [L,V,I,A]-X1-X2-[L,V,I,A]-[D,E
Insulin is a relatively simple protein consisting of 51 amino acids arranged as two polypeptide chains, an α- chain and β-chain, connected by disulfide bonds; the latter are necessary to maintain tertiary structure and biological activity. Although the amino acid sequence and composition of animal...
Theamino acid sequencesof insect ILPs are highly diverged between insect orders, except for some critical residues (such as Cys) necessary fortertiary structureformation. However, they can be grouped into at least three classes based mainly on the sequence features of their precursor: insulin (bom...
The antigen sequence used for immunization was an appropriately phosphorylated polypeptide corresponding to amino acids 311 to 323 of PPP1CB (C-SGRPV-pT-PPRTANP). Rabbits were immunized with BSA-conjugated peptide. Sera were collected after the third immunization, and then we performed affinity ...
Phylogenetic analysis using protein sequences indicated that this molecule could be classified in the Insulin group, not the IGF group or Relaxin group (Supplementary Fig. S2a). Thus, phylogenetic analyses indicated this new factor should be called Insulin3. Insulin3 consists of 100 amino acids (...
and thereby controls its concentration in the blood. Insulin was the first protein whose amino acid sequence was fully determined(in 1955). Underproduction of insulin results in the accumulation of large amounts of glucose in the blood and its subsequent excretion in the urine.This condition, kno...
The consensus sequence for an ATP-binding domain is located between amino acid residues 1003−1030. The locations of all of the mutations reported to cause insulin resistance are noted on the right. TABLE I. Genetics of Insulin Resistancea MutationSyndromeReference Simple homozygotes (consanguineous...
ChemInform Abstract: SYNTHESIS OF A PROTECTED HEXAPEPTIDE IN THE INSULIN B 9-14 PARTIAL SEQUENCEamino acids, peptidesNois available for this article.doi:10.1002/chin.197738345LOSSE, G.SCHUMACHER, K.-J.Cheminform
sequenceThis communication reports the complete amino acid sequence (263 amino acids) for the insulin-like growth factor binding protein 1 in the bovine (blGFBP-1). It is 70% homologous with the equivalent IGFBP-T in human and rat.doi:10.3109/10425179109020798...
connection portion comprises 6 to 16 monomer units of polyethylene glycol, while in alternative embodiments, the connection portion comprises a peptide derived from the IGF-1 C, and contains at least eight amino acids in length and not more than 12 non-native amino acid sequence of amino acids...