Insulin secretion in response to protein ingestion. J Clin Invest 1966;45:1479-1486Floyd JC Jr, Fajans SS, Conn JW, Knopf RF and Rull J. Insulin secretion in response to protein ingestion. J. Clin Invest. 45:1479-86, 1966.Floyd JC Jr, Fajans SS, Conn JW, Knopf RF, Rull J. ...
To determine whether the enhanced insulin-sensitivity of glucose metabolism in muscle after acute exercise also extends to protein metabolism, untrained and exercise-trained rats were subjected to an acute bout of exercise, and the responses of protein synthesis and degradation to insulin were measured...
The role of insulin in the regulation of muscle protein synthesis in adult humans has been investigated with intravenous infusion of insulin at levels comparable with those observed after normal feeding. Glucose was also infused to maintain euglycemia. Muscle protein synthesis was measured in six hea...
We and Boitard and co-workers have recently reported that breeding the insulin 2 gene knockout onto NOD mice accelerates the development of diabetes while in contrast, insulin 1 knockout mice were protected from diabetes, which may relate to differential thymic expression of protein [18], [19]...
However, the exact molecular mechanisms behind this response are not well understood. Thus, the aim of this study was to determine the dynamics in protein expression and phosphorylation of key components in insulin signaling in subcutaneous (SCAT) and retroperitoneal (RPAT) adipose tissues of ...
(DKO-IR-A) treated with the indicated ligands for 10 min. Levels of protein phosphorylation were normalized to total protein levels and shown as intensities relative to that in 1000 nM IGF2 WT-treated cells.N = 4 independent experiments. Significance calculated using two-tailed Student...
Regulation of hypoxia-inducible factor-1α, regulated in development and DNA damage response-1 and mammalian target of rapamycin in human placental BeWo ce... JF, Giorgetti-Peraldi S (2012) Regulated in Development and DNA Damage Responses-1 (REDD1) protein contributes to insulin signaling pathway...
protein amounts for phosphoproteome analyses restricted our studies to SEC-isolated AdEVs from DIO mice. The glucose bolus induced a strong phosphorylation response on the MIN6 proteome that was significantly exacerbated when MIN6 cells were pretreated with DIO AdEVs (Fig.4f). This response included...
1f). Next, the response of WDR6 to insulin in cultured cells was checked. We constructed a genetically stable HepG2 cell line with endogenous expression of a WDR6–FLAG fusion protein (in regulation of endogenous WDR6 promoter; WDR6–FLAG cells; Extended Data Fig. 1a,b). The cells were...
Insulin-like growth factor binding protein-3 carries most of the circulating IGFs. While insulin regulates serum IGFBP-1 concentration, the effect of insulin on IGFBP-3 concentration is not known. We examined the IGFBP-3 response to hyperinsulinemia in healthy subjects and diabetic patients. Serum ...