瘦素抵抗(leptin resistance) 与Insulin resistance一样对机体会造成负面影响。 瘦素是由脂肪细胞分泌,发出信号给大脑,机体有了足够能量不需要继续进食了。功能是抑制食欲,增加能量消耗,抑制脂肪合成。 瘦素抵抗影响大脑接受信号。 体重上升,瘦素上升,瘦素抵抗,瘦素水平进一步上升,加重瘦素抵抗。///恶性循环/// -少食用
Insulin resistanceLeptinCoronaryStentIn-stent restenosis remains the major limitation of coronary stent implantation. Leptin is a hormone strongly related to insulin resistance (IR). Moreover, insulin resistance and hyperinsulinemia are common in patients with coronary heart disease (CHD), each of the ...
Insulin and Leptin Resistance Resistance to the effects of insulin represents a key process in the development of type 2 diabetes mellitus (T2DM) (Bruning et al., 1997; Kahn, 1994). At first, in the prediabetic state, the β cells of the pancreas increase insulin secretion to compensate for...
Under normal conditions, insulin promotes hepatic de novo lipogenesis (DNL). However, during insulin resistance (IR), when insulin signalling is blunted and accompanied by hyperinsulinaemia, the promotion of hepatic DNL continues unabated and hepatic ste
Reversal of Insulin Resistance by Leptin(1)|by|insulin|leptin|of|resistance|reversalThe insulin resistance of type II diabetes appears to be caused in part by the presence of high levels of lipids in cells such as skeletal muscle where this would not nor
Obesity is known to be associated with adipose tissue inflammation and insulin resistance. Importantly, in obesity, the accumulation of proinflammatory macrophages in adipose tissue correlates with insulin resistance. We hypothesized that the receptor fo
Those markers include inflammation, insulin resistance and oxygen free radicals.───那些指标包括炎症,胰岛素抵抗力和氧自由基。 There were positive correlations between insulin resistance and leptin levels.───胰岛素抵抗与瘦素水平显著正相关. This process is sluggish if you have insulin resistance.──...
The insulin resistance of type II diabetes appears to be caused in part by the presence of high levels of lipids in cells such as skeletal muscle wher
5 Others possible molecules suggested to be involved in the development of insulin resistance in obesity are tumour necrosis factor-α (TNF-α), adiponectin, resistin and leptin.2 View article Review article Treatment of the adolescent patient with polycystic ovary syndrome Obstetrics and Gynecology ...
Moreover, environmental pollution causes 尾-cell dysfunction which can adversely affect insulin synthesis , secretion, increase insulin resistance, and promote development of type 1 and type 2 diabetes mellitus . This chapter provides current information on insulin synthesis and secretion, and the impact...