Mitochondrial oxidative stress is associated with exercise-induced muscular fatigue and insulin resistance. Catalase is an antioxidant enzyme catalyzing the breakdown of HOinto HO and O. We hypothesized that reducing oxidative stress by mitochondrial catalase overexpression would improve exercise- and insulin...
II型糖尿病:首先从胰岛素抵抗(insulin resistance)开始,也就是说细胞对胰岛素没有反应。正常情况,胰岛素与细胞表面受体结合,由此激活细胞膜表面的葡糖糖转运分子形成一条门径,使得葡萄糖进入细胞。然而,胰岛素抵抗发生,细胞对胰岛素信号反应明显降低,门径形成降低,导致很多葡萄糖挡在细胞外(留在血液中)。 II型糖尿病很难...
Reactive oxygen species (ROS) are well known for their role in insulin resistance and the development of cardiometabolic disease including type 2 diabetes mellitus (T2D). Conversely, evidence supports the notion that ROS are a necessary component for glucose cell transport and adaptation to physiologic...
insulin resistance, and type 2 diabetes.6 According to Wood, an overabundance of fatty acids also may result in the abnormal deposition of fat in both liver and muscle tissues.5 Indeed, studies have shown a strong positive relationship between the accumulation of fat in muscle tissue and insulin...
Insulin resistance (IR) is defined as the inability to activate receptor sites on cells to receive glucose. In other words the cells are not responding to the message of insulin
and resistance to muscle fatigue, despite reducing muscle force. This seemingly paradoxical phenotype is due to lower glucose utilization and greater lipid oxidation in HDAC3-depleted muscles, a fuel switch caused by the activation of anaplerotic reactions driven by AMP deaminase 3 (Ampd3) and ...
Intype 1 diabetes, the pancreas cannot produce insulin. Type 1 diabeteswas formerly known as juvenile diabetes or insulin-dependent diabetes.Type 2 diabetesis more a result ofinsulin resistance(cells not being able to use insulin effectively or at all. It was formerly known as adult-onset diabete...
Interventional studies of testosterone replacement therapy have shown improvements in insulin resistance, body composition, glycaemic control, lipid metabolism and other cardiovascular risk factors The benefit of testosterone on insulin sensitivity might be attributable to a complex regulatory influence on insuli...
insulin secretion is reduced and resulting high blood sugar rises out of control, creating a condition called adult onset diabetes mellitus (also called Type 2 diabetes) that affects over 16 million Americans. This is why it is so important to find a way to reverse insulin resistance naturally....
antibodies to the hormone or its receptor, oversecretion of growth hormone or adrenal steroids, ketosis, and unknown genetic factors all cause insulin resistance. Muscular exercise, correction of obesity, and a deficiency of pituitary or adrenal hormones are associated with an increased sensitivity to...