sugar/ blood glucose regulationstochastic optimal controlinsulin-dependent diabetic patientsDiabetes is a disease resulting from the impaired mechanism of insulin secretion from the pancreas, which prevents glucose from entering the cells and being utilized and leads to wide swings of blood sugar and ...
depots in response to glucose fluctuations, but such systems are limited by delayed glucose diffusion to the subcutis, as well as a delay in the released insulin entering the blood circulation. Moreover, such systems release insulin irreversibly, meaning that, once the insulin is released from ...
8% of M cells indaf-16mutants failed to arrest cell division in response to starvation (Fig.1c), consistent with previous observations6. Thus, SSU-1 is required for developmental arrest in response to osmotic stress but is not required...
Obesity leads to an increase in inflammation and insulin resistance. This study determined antioxidant activity of flaxseed and its role in inflammation and insulin resistance in obese glucose intolerant people. Using a randomized crossover design, nine
For quantification of glucose, hemolymph from 15 larvae was diluted 1:100 and incubated at 70°C for 5 min. TAG levels were determine using a serum triglyceride determination kit (Sigma, TR0100) according to the manufacturer’s protocol. For glycogen measurements, 40 μl of heat-treated ...
Primary white adipose tissue, which was used as the standard in our previous study35, was biopsied from the subcutaneous fat of a 47 year-old Caucasian female with BMI of 25.6; fasting blood glucose of 94 mg/dL, A1C of 4.8%; exclusion factors include smoking, unstable weight within ...
In addition to its primary function in maintaining glucose blood levels and protein synthesis, insulin also participates in cell differen- tiation, with important metabolic and mitogenic effects mediated by an insulin receptor present in virtually all vertebrate tissues [11]. In reptiles, several ...
Production of IL-1β-induced inflammation in β-cells of pancreatic islets. Prolonged exposure of FFAs and glucose induce the activation of IL-1β from β-cells of pancreatic islets through the involvement of various transcriptional mediated molecular pathways notably TXNIP, MYD88, NF-κB, TLRs, ...
TXNIP protein negatively regulates glucose uptake in cells via its role as a GLUT1 adaptor to the clathrin-mediated endocytosis machinery (Parikh et al., 2007, Wu et al., 2013). This supports the model in which TXNIP suppresses glucose influx: too much glucose entering the cell induces the ...
However, this decrease was more pronounced when the cells were treated with severe hyperglycemic conditions and PA (0.58 ± 0.07, fold variation to control) compared with those from the groups treated with increasing concentrations of glucose, although with no statistical differences. Download: ...