The following adverse reactions have been identified during post approval use of LEVEMIR. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Medication e...
However, possible side-effects on cardiovascular functions after intravenous (IV) administration have not been reported. This study describes the Exendin-4 dose at which cardiovascular side-effects occur in pigs and cynomolgus monkeys. The IV effect of the tracer on insulin secretion is also ...
Eight novel podophyllotoxin-like derivatives were synthesized and assayed for toxicity and functional activity toward PPARγ to reduce the possible systemic toxic effects of podophyllotoxin and to maintain partial agonist activity toward PPARγ. Cell-based transactivation assays showed that compounds (E)-3...
Bruising of skin is possible ■ Mechanically complex ■ Some older models must be cleaned and sterilized ■ Not well studied in trials Side effects of insulin therapy The most common adverse reactions to insulin are: ■ Weight gain [162, 163]; ■ Hypoglycaemia [164]; ■ Insulin allergy and ...
We recently showed that phanoside, a gypenoside isolated from the plant Gynostemma pentaphyllum, stimulates insulin secretion from rat pancreatic islets. To study the mechanisms by which phanoside stimulates insulin secretion. Isolated pancreatic islets of normal Wistar (W) rats and spontaneously diabeti...
If and when the ideal glitazar is developed, it would fill the niche of potentinsulin sensitizerwith potenthypolipidemiceffects and possible weight neutrality. The reports from animal studies suggest that such an agent would also have salutary effects on other aspects of themetabolic syndromeincluding...
Insulin peptides were not possible to included in the DNA-only simulations but insulin peptides (red) were drawn in afterwards to illustrate their scale. d, Optimization of conjugation conditions of insulin to DNA. Images of native polyacrylamide gels stained with SYBR Gold to visualize azide-DNA...
This study examined the induced changes in muscle mass and insulin sensitivity in postmenopausal women after 6-month exercise training along with their possible correlations. 展开 关键词: MUSCLE MASS INSULIN SENSITIVITY MIXED EXERCISE TRAINING MENOPAUSE ...
International Journal of Molecular Sciences Article Insulin-Like Growth Factor-1 as a Possible Alternative to Bone Morphogenetic Protein-7 to Induce Osteogenic Differentiation of Human Mesenchymal Stem Cells in Vitro Bruno Reible 1, Gerhard Schmidmaier 1, Arash Moghaddam 1,2 and Fabian Westhauser 1...
Various factors and signaling have been studied for their potential effects on IPC generation in vitro. In this regard, Notch signaling was of interest due to its significant effect during pancreatogenesis both in vivo and in vitro89,90,91,92. cAD-MSC-derived IPCs were generated using the opti...