Insulin is produced in the pancreas and is responsible for regulating delivery of glucose (sugar) into cells to provide them with the material to create energy. In insulin resistance the normal receptors on the cell walls that “open up” the cell to let in the sugar do not work. Consequent...
It will be interesting to explore whether ERRα is responsible for insulin-stimulated glucose disposal in skeletal muscle that are independent of the PI3K-AKT signaling pathway, as attenuation of refeeding-induced AKT phosphorylation is minimal in ERRα3SA muscle, and multiple studies revealed ...
Insulin resistance is a prominent feature of insulin-dependent diabetes. Patients with non-insulin-dependent diabetes mellitus (NIDDM) are at increased risk for stroke. Hyperuricemia is a common finding in NIDDM, but its signifi... R A,DeFronzo,Hendler,... - 《Diabetes》 被引量: 829发表: 198...
Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus. BACKGROUND AND PURPOSE: Patients with non-insulin-dependent diabetes mellitus (NIDDM) are at increased risk for stroke. Hyperuricemia is a common finding i... S Lehto,L Niskanen,T Ronnemaa...
J. et al. Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway. Oncogene 28, 686-697, doi:10.1038/onc.2008.417 (2009)....
This process is responsible for inhibiting PPAR-target genes, such as CAP and IRS-2. Our study shows that IKK promotes the activity of HDAC3 in the nuclear corepressor complex. IKK induces nuclear translocation of HDAC3 from the cytoplasm. In the cytosol, HDAC3 associates with IκBα, and ...
1. (C) Proposed model of RLIP function. The example presented is for EGF-EGFR-mediated signaling. The EGF-EGFR system induces growth, differentiation, migration, adhesion, and cell survival through various interacting signaling pathways. Activation of EGFR leads to homo/heterodimerization, ...
the MAPK pathway is relatively unaffected by IR.20 MAPK pathway activation by insulin signaling is responsible for gene expres- sion, cell growth, and mitogenesis.4 MAPK acts as an IRS serine kinase in certain conditions;15 therefore, inappropriate activa- tion of MAPK may worsen IR by increasin...
(blood compartment) PK profile would mimic the pattern of insulin secreted from the pancreas directly into the portal circulation where the liver is highly exposed. This peaked PK profile upon oral delivery with greater liver effect is not expected to be the same as what was observed for ...
Peptidylglycine 伪 -amidating monooxygenase (PAM), the enzyme responsible for the 伪 -amidation of neuroendocrine peptides, is more prevalent in the atrium... JY Maltese,AM Oyarce,BA Eipper - 《Journal of Molecular & Cellular Cardiology》 被引量: 18发表: 1996年来源...