Insulin glargine may interact with medications such as: Rosiglitazone Side Effects: There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug. Watch out for signs of allergic reactions such as: Rash Itching Swelling ...
This other insulin glargine product was given to female rats before mating, during mating, and throughout pregnancy at dose up to 0.36 mg/kg/day, which is approximately 7 times the 2 recommended human subcutaneous starting dose of 10 units/day (0.008 mg/kg/day) based on mg/m . In ...
Because of this dependency on pH, glargine should not be diluted or mixed with anything that may change the pH of the solution. Glargine forms microprecipitates in the subcutaneous tissue at the site of injection from which small amounts of insulin glargine are slowly released and absorbed...
Related to continuous subcutaneous insulin infusion:insulin pump in·fu·sion (ĭn-fyo͞o′zhən) n. 1.The act or process of infusing. 2.Something infused or introduced:an economy in need of regular capital infusions. 3.The liquid product obtained by infusing:prepared an infusion of ...
These degradation products are present both at the injection site and in plasma.Thus, during treatment with a subcutaneous injection of insulin glargine, metabolic degradation is likely to be initiated at the injection site and continued within the circulatory system.Current medical research and opinion...
acid and sodium hydroxide. TOUJEO has a pH of approximately 4. At pH 4, insulin glargine is completely soluble. After injection into the subcutaneous tissue, the acidic solution is neutralized, leading to formation of a precipitate from which small amounts of insulin glargine are slowly released...
Administer insulin glargine or insulin glargine/lixisenatide only if solution is clear and colorless with no particles visible.DosageDosage of insulin glargine is expressed in units.Dosage of insulin glargine/lixisenatide has been expressed in terms of the insulin glargine component; however, each mL ...
傳送路徑胰島素的傳送路徑有:1.皮下投予(Subcutaneousadministration)乃是藉由注射器注射到皮下組織,其吸收的速率主要視注射位置血管分佈的多寡,藥物圖一的脂溶性及解離程度來決定.一般皮下吸收比肌肉吸收來得慢.目前絶大部份胰島素皆是以此種方式來投予[3]。2.口服投予(Oraladministration)儘管口服投...
Three types of long-acting insulin for subcutaneous injection exist on the market in the United States: detemir, glargine, and degludec. Detemir has a myristic acid attached to lysine at the B chain position 29 (B29), with a deletion of B30, and has an onset of action within 3 to 4 ...
Insulin balls, localized insulin amyloids formed at subcutaneous insulin-injection sites in patients with diabetes, cause poor glycemic control owing to impairments in insulin absorption. Our previous study has shown that some insulin balls are cytotoxic, but others are not, implying amyloid polymorphism...