The pharmacological effects of glargine, protamine zinc (PZI), and lente insulins were evaluated in nine healthy cats. A 3-way crossover study was performed and plasma concentrations of insulin and glucose were determined for 24 h after a single subcutaneous injection of each insulin at 3-day ...
The pharmacological effects of glargine administered once or twice daily were compared in six healthy cats. A two-way crossover study was performed with insulin and glucose concentrations measured following subcutaneous administration of glargine once daily (0.5 U/kg) or twice daily (0.25 U/kg, rep...
The pharmacological effects of glargine administered once or twice daily were compared in six healthy cats. A two-way crossover study was performed with insulin and glucose concentrations measured following subcutaneous administration of glargine once daily (0.5 U/kg) or twice daily (0.25 U/...
This insulin forms soluble multihexamers after subcutaneous injection, resulting in an ultra-long action profile with half life more than 24 h. Insulin degludec has proven to be non inferior to insulin glargine in clinical trials carried out in both type 1 and type 2 DM. Exploratory studies in...
In T1D, adjunctive therapies are less common as insulin replacement is an absolute requirement but those that target additional pharmacological pathways such as amylin analogues [137], GLP-1 receptor agonists and SGLT2 inhibitors continue to be evaluated [34,138]. In T2D, the multifactorial and ...
Specificity of insulin sensitivity can be further verified by pretreating the cells with pharmacological inhibitors of insulin action (wortmannin, cytochalasin B, genestein, etc.) followed by insulin treatment (Vijayakumar et al., 2005, 2010). View chapterExplore book Biodiversity and Natural Product ...
terminus of the b chain. 13·15 it is available as a solution at ph 4; on subcutaneous injection and neutralisation by tissue buffering processes, microprecipitates are formed that slowly release insulin glargine over 24 hours with no pronounced peak in concentration or in metabolic activity. as...
Glargine and protamine zinc insulin have a longer duration of action and result in lower mean daily glucose concentrations than lente insulin in healthy cats The pharmacological effects of glargine, protamine zinc (PZI), and lente insulins were evaluated in nine healthy cats. A 3-way crossover ...
On the other hand, pharmacological therapy is generally adopted due to its ease of use and low cost2,11. Among the drugs available on the market, alloxan and streptozotocin are the most used. The percentage of animals induced into diabetic status after an intravenous s...
Its onset of action is approximately 1 h and its slow release from microprecipitates provides a relatively constant concentration of insulin over 24 h. Due to these pharmacological properties, it has been suggested that this type of insulin may have a role in facilitating the transition from ...