These guidelines are not intended to interfere with clinical judgment. Rather, they are intended to assist practitioners in providing consistent, high quality cost effective care.Deborah KhachikianPharm.D
Long-acting insulins aren’t tied to mealtimes. You’ll take detemir (Levemir)once or twice a day no matter when you eat. And you’ll take glargine (Basaglar, Lantus, Toujeo)once a day, always at the same time. Deglutec is taken once a day, and the time of day can be flexible...
Human recombinant insulin, insulin lispro, insulin aspart, and insulin glargine are the commonly-used insulins. Beef and pork insulin are infrequently used. Regular human insulin (Novolin R, Humulin R) is available in vials, cartridges, and prefilled syringes. NPH human insulin (Novolin N, ...
Exogenous insulins, including the newer biosynthetic insulins (i.e. aspart, detemir, glargine, glulisine, lispro) appear to be excreted into breast milk. Insulin is a protein that is inactivated if taken by mouth. If absorbed, it would be destroyed in the digestive tract of the infant. ...
[NPH], lispro, glulisine, glargine, detemir, degludec, and aspart), delivery devices (vials/syringes or pens), therapeutic class (short-acting, rapid-acting, long-acting, intermediate-acting, and premixed insulin), insulin type (human, analog, and biosimilar), and date of approval (newer: ...
(insulin lispro, insulin aspart, insulin glargine—with very fast, fast, long-acting, respectively) and for different modes of administration (intramuscular, subcutaneous, etc.). Other than insulin, recombinant growth hormone is used to treat growth disorders. Somatropin, a widely used recombinant ...
If converting from insulin glargine to LEVEMIR, the change can be done on a unit-to-unit basis. If converting from NPH insulin, the change can be done on a unit-to-unit basis. However, some patients with type 2 diabetes mellitus may require more LEVEMIR than NPH insulin, as observed in...
Rhoads GG, Kosiborod M, Nesto RW, Fonseca VA, Lu SE, Zhang Q, Foody JM: Comparison of incidence of acute myocardial infarction in patients with type 2 diabetes mellitus following initiation of neutral protamine Hagedorn insulin versus insulin glargine. Am J Cardiol. 2009, 104: 910-916. 10.1...
Long-acting insulins aren’t tied to mealtimes. You’ll take detemir (Levemir)once or twice a day no matter when you eat. And you’ll take glargine (Basaglar, Lantus, Toujeo)once a day, always at the same time. Deglutec is taken once a day, and the time of day can be flexible...
These analogs have been formulated into either bolus insulin analogs (lispro, aspart, and glulisine) or basal insulin analogs (glargine, detemir, degludec, and icodec) (Table 2). Table 1. Insulin analogs, their onset time, time to peak serum concentration, and duration of drug action. ...