We report the death of a young female non-diabetic after self-administration of insulin which led to the trial and conviction of her partner, who was himself an insulin-dependent diabetic. This brings out particular lessons for the pathologist in view of the rarity of such deaths, emphasizes ...
OBJECTIVE: To investigate the contributions of intact proinsulin and of des-31,32-proinsulin to fasting concentrations of insulin-like molecules in nondiabetic subjects from two ethnic groups (Asian and white) and to see whether Asian subjects are hyperinsulinemic compared with white subjects using hig...
To examine hyperinsulinemia, insulin secretion, and beta-cell function in Pima Indians, South Asians, and whites, populations at varying risk of diabetes.We investigated 136 Pima Indian, 98 Asian, and 80 white nondiabetic and 172 Pima Indian, 40 Asian, and 49 white diabetic subjects. Highly sp...
We tested the hypothesis that a particular immune activation profile might be correlated with insulin resistance in a general population. By measuring 43 markers of immune, endothelial, and coagulation activation, we have previously shown that five diffe
Insulin receptor (IR) controls growth and metabolism. Insulin-like growth factor 2 (IGF2) has different binding properties on two IR isoforms, mimicking insulin’s function. However, the molecular mechanism underlying IGF2-induced IR activation remains u
(from MASS package65in R) since it was the best way to approximate a normal distribution. We conducted analyses in SPRING and MOMS cohorts using plasma IGFBP1 levels without transformation, given distributions that were relatively normal. We used Pearson correlations between circulating IGFBP1 ...
Switching to once-weekly insulin icodec versus once-daily insulin glargine U100 in basal-bolus insulin-treated type 2 diabetes (ONWARDS 4): a phase 3, randomised, open-label, treat-to-target, non-inferiority trial. Lancet. 2023;401(10392):1929-1940. doi:10.1016/S0140-6736(23)00520-2...
The effects of combined insulin and sulfonylurea therapy on glycaemic control and B-cell function was studied in 15 Type 2 (non-insulin-dependent) diabetic... S Stenman,PH Groop,C Saloranta,... - 《Diabetologia》 被引量: 632发表: 1988年 When oral agents fail: practical barriers to startin...
Given the ubiquitin-proteasome system (UPS) is a major mechanism regulating protein turnover24, we assessed and observed that MG132-mediated inhibition of the proteasome led to accumulation of ERRα protein without altering its mRNA level (Supplementary Fig. 3d, e). In the refed liver, ERRα ...
4a–c). Given food intake was held constant, the body weight curves showed a slightly decreased body weight in WDR6-LKO than wild-type (WT) littermate control (LC) mice (Extended Data Fig. 4d,e). Compared to LC, male WDR6-LKO mice showed decreased serum TAG and FPG levels (Extended...