Increased airway hyperreactivity after pHA despite unaltered bronchial structure. Beside the aforementioned functions, insulin and leptin promote fibrotic processes and increase contractility, contributing thereby to increased airway resistance20,31,38,39. In our study we report airway hyperreactivity ...
Renal cell carcinoma (RCC) has emerged as a metabolic disease characterized by dysregulated expression of metabolic enzymes. Patients with metastatic RCC have an unusually poor prognosis and near-universal resistance to all current therapies. To improve
Diabetes Mellitus The condition brought about by decreased insulin production, or the inability of the body cells to use insulin properly (which prevents the body’s cells from taking the simple sugar called glucose from the bloodstream) It is a metabolic disease Glucose nBnBody’s basic form of...
2000). However, whether CAMK4 controls IR in trophoblast cells via regulating NUR77 expression is undetermined. Metabolites are the end products of transcription, translation and proteome and therefore reflect pathophysiologic functions from cells to tissues (Juppner et al. 2017). Metabolomics analysis...
MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma. Oncogenesis. 2012;1:e3. Article PubMed Central CAS PubMed Google Scholar Wellner U, Schubert J, Burk UC, et al. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol. ...
Normal expression of Cdc42 not only plays critical roles in normal islet functions including cytoskeletal remodelling, vesicular transport and fusion, insulin secretion and β cell proliferation but also is essential for glucose-stimulated induced insulin secretion (GSIS) to occur [13]. In recent ...
pancreas hormone functions. The discussion also will explore the adverse effects of RA on estrogen action, in contrast to the enhancing effects of estrogen on RA action, the adverse effects of androgens on RA receptors, and the RA induction of androgen biosynthesis. Keywords: adiposity; androgen;...
Hemin can selectively bind to some proteins such as transcription factors, kinases and receptors, and thereby alter gene transcription, protein synthesis and related biological functions [3]. Hemin binds to the transcriptional repressor Bach1, and regulates the transcription of some antioxidant enzymes ...
Triglyceride levels must remain within a very narrow range in nonadipose cells; therefore, when adipose tissue systematically releases large amounts of FFAs, the increased storage of triglycerides together with IR lead to cell death, toxic effects, and impairment of the functions of nonadipose ...
The main reason for the intensified morbidity of this type of diabetes is the increasing incidence of obesity particularly common in well-developed countries [3]. The excessive body weight gain, which is a significant cause of obesity, is inseparably associated with a chronic, moderately-...