Initial insulin glargine doses were similar among all weight groups: median (range) 0.299 (0.227-0.4), 0.297 (0.204-0.421), and 0.291 (0.194-0.394) units/kg/dose, respectively, for the underweight, normal weight, overweight/obese groups. No significant differences in discharge fasting glucose ...
When stratified by sex, women presented a significantly dose-dependent trend of 1-OHP with HOMA-IR (p trend=0.013), whereas no association was observed in men (p trend=0.904). When further stratified by weight (body mass index ≥25 vs <25 kg/m2), a significant association was ...
BACKGROUND: This study assessed insulin dose and dosing patterns required to optimize glycemic control with an insulin pump in patients with type 2 diabete... SV Edelman,BW Bode,TS Bailey,... - 《Diabetes Technol Ther》 被引量: 89发表: 2010年 Insulin-induced weight gain and cardiovascular ev...
Secondary safety end points included mean total weekly insulin dose during the last 2 weeks of treatment; change in body weight from baseline to week 26; and the number of level 2 (clinically significant; glucose level <54 mg/dL, confirmed by blood glucose meter), level 3 (severe; hypoglyce...
Herein, the response to a range of doses of IGF-I was investigated and we hypothesized that LPH and villus height would respond to oral IGF-I in a dose-dependent manner. Two 14-d experiments were conducted using cesarean-derived piglets. In experiment 1, piglets (n = 28) were fed ...
Chronic insulin treatment was ineffective in promoting changes in animals receiving any dose of insulin except the highest dose. Animals receiving 5.0 IU/day insulin + GLU experienced a transient hyperphagia and weight gain followed by a suppression in food intake and body weight by Day 4 of ...
Introducing a simplified approach to insulin therapy in type 2 diabetes: a comparison of two single-dose regimens of insulin glulisine plus insulin glargin... Aim: To investigate whether the addition of a single bolus of insulin glulisine (glulisine), administered at either breakfast or main me...
degludec versus the baseline dose of the previous basal insulin [27], insulin doses were modeled as end-of-study doses in both simulation arms and a mean end-of-study body weight of 65 kg was assumed (derived from the mean baseline BMI value of 25.0 kg/m2 reported in the KIDUNA ...
Mitohormesis: promoting health and lifespan by increased levels of reactive oxygen species (ROS). Dose-Response Publ Int Hormesis Soc. 2014;12:288–341. CAS Google Scholar Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin CT, Price III JW, Kang L, Rabinovitch PS, Szeto HH...
Figure 3illustrates the utilization of restricted cubic splines to visualize and analyze the dose-relationship between four IR surrogates and hyperuricemia in the middle-aged and elderly Chinese population. After adjusting for multiple variables, we observed nonlinear relationships for TG/HDL-C (pfor no...