These results indicate that a substantial age-related decrement in 2-DG uptake occurs in several limb muscles from rats at 21 vs. 28-35 days by a mechanism that is independent of GLUT-4 levels and not specific for the insulin-dependent pathway. 展开 ...
Insulin resistance instills when target tissues lose their responsiveness to the hormone and has long been considered to be central to the pathophysiology of metabolic disorders such as type 2 diabetes (T2D), obesity, cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD)3. Insulin ...
Asian Indians are at higher risk for diabetes and cardiovascular disease than European Caucasians. To examine the pathophysiology of this increased risk, we measured insulin sensitivity, cardiovascular risk factors, fat distribution, and endothelium-dependent (reactive hyperemia) and -independent (nitroglyce...
To explore whether changes were present already at the level of prediabetes, we compared the BD þ IR/GI Neuropsychopharmacology participants with the combined group of euglycemic participants (euglycemic BD and euglycemic controls subjects) using an independent samples t-test. To investigate the ...
Middle Eastern immigrants to western countries are at high risk of developing type 2 diabetes. However, the heritability and impact of first-degree family
Here are some detailed explanations of independent and dependent risk factors directly or indirectly associated with obesity. 4.1. Environmental factors Environmental factors increase the risk of becoming overweight and obese. Nowadays, the communities are structured in a way that it may pose a risk ...
Nathan DM, Genuth S, Lachin J, et al; Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329(14):977-986.PubMedGoogle ...
Driving and insulin-independent diabetes. Lancet. 1981 Aug 15; 2 (8242):354–356.Frier BM, Matthews DM, Steel JM, Duncan LJP. Driving and insulin-dependent diabetes. Lancet 1980; i: 1232-4.Frier BM, Matthews DM, Steel JM, Duncan LJP: Driving and insulin-dependent diabetes. Lancet 1:...
20 years of pediatric benchmarking in Germany and Austria: age-dependent analysis of longitudinal follow-up in 63,967 children and adolescents with type 1 diabetes. PLoS One. 2016;11(8):e0160971.PubMedGoogle ScholarCrossref 3. Sherr JL, Hermann JM, Campbell F, et al; T1D Exchange ...
Sex-related differences in insulin sensitivity were evaluated in male and female adolescents with insulin-dependent diabetes mellitus (IDDM). They were matched for age, pubertal staging, body mass index, and glycohemoglobin levels. During a 1.7 mU/kg.min hyperinsulinemic-euglycemic clamp, the insulin...