Insulin-dependent diabetes mellitus (IDD) affects between one in 250 and one in 500 Americans. The inheritance of IDD is non-Mendelian and polygenic. Genetic susceptibility predominantly results from specific alleles in the HLA complex and insulin gene region. Autoimmune destruction of pancreatic beta...
Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease, where the insulin-producing β-cells in the pancreatic islets are selectively dest
An unselected population of 755 siblings of children with insulin-dependent diabetes mellitus (IDDM) was studied to evaluate the predictive characteristics of islet cell antibodies (ICA), antibodies to the IA-2 protein (IA-2A), antibodies to the 65-kD isoform of glutamic acid decarboxylase (GADA...
Insulin:Bcells――synthesis－→secretion――bloodcirculation－→targetcells－→bindingwithinsulinreceptor－→intracellularsubstancemetabolism anylinkgoingwrong－→diabetesmellitus Overview DiabetesMellitus――long-termdisease――multisystemdamage－→functionaldefectandfailure Severe－→diabeticketoacidosis－...
While Type 1 Diabetes Mellitus (T1DM) is characterized by hypoinsulinemia and hyperglycemia, persons with T1DM also develop insulin resistance. Recent studies have demonstrated that insulin resistance in T1DM is a primary mediator of the micro and macrov
The incidence of Type I diabetes has not increased but shifted to a younger age at diagnosis in the 0-34 years group in Sweden 1983-1998 Aims/hypothesis. To analyse the incidence of Type I (insulin-dependent) diabetes mellitus in the 0–34 years age group in Sweden 1983–1998.Methods. ...
Genomic structure and promoter sequence of the insulin-dependent diabetes mellitus autoantigen, IA-2 (PTPRN). IA-2 is a transmembrane protein tyrosine phosphatase, expressed in neuroendocrine cells, and a major autoantigen in insulin-dependent diabetes mellitus. In... J Xie,B Zhang,MS Lan,... ...
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Effect of Diabetes and its Control on Insulin-like Growth Factors in the Young Subject with Type I Diabetes The influence of diabetes and its control on circulating levels of growth hormone and growth hormone-dependent, insulin-like growth factors (IGF) remains controversial. In the present study...
Insulin resistance in type 2 (non-insulin-dependent) diabetic patients and their relatives is not associated with a defect in the expression of the insulin... To study whether insulin resistance in Type 2 (non-insulin-dependent) diabetes mellitus is due to a defect in the expression of the ...