Potassium channels belong to the most diverse family of ionic channels that includes ATP-dependent potassium (KATP) channels in the potassium rectifier channel subfamily. These channels were initially described in heart muscle and then in other tissues such as pancreatic, skeletal muscle, ...
Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia. J Hyperten 2008; 26: 2326–38. 27 Pollare T, Lithell H, Berne C. Insulin resistance is a characteristic feature of primary hypertension in dependent of ...
In mammals an increase in glucose leads to block of ATP dependent potassium channels in pancreatic β cells leading to membrane depolarization. This leads to the repetitive firing of action potentials that increases calcium influx and triggers insulin granule exocytosis. Several important differences betw...
The injectable glucagon-like peptide-1 receptor agonists (GLP-1 RAs) (liraglutide, exenatide, lixisenatide, dulaglutide, and albiglutide) mimick the effects of endogenous GLP-1, thereby stimulating pancreatic insulin secretion in a glucose-dependent fashion, suppressing pancreatic glucagon output, slowing ...
Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic β-cells. Pflü- gers Arch 1986; 407: 493–499. 190 Skoglund G, Ahrén B, Lundquist I. Biochemical determination of islet lysosomal enzyme activities following crinophagy-stimulating treatment with ...
OBJECTIVE: Exposure to anoxia has been reported to activate ATP-sensitive potassium (K+(ATP)) channels in isolated ventricular myocytes. We aimed to invest... S Sakuji,A Makoto - 《Cardiovascular Research》 被引量: 123发表: 1997年 Inhibition by histamine H1 receptor antagonists of endogenous gl...
Regrettably, two important areas, the beta cell ATP-sensitive potassium channel and the glucose transporter, were among these. Nevertheless, the authors who con tributed have done an excellent job, and we would like to thank them for their diligence. 展开 ...
Regulation of insulin secretion via ATP-sensitive K+ channel independent mechanisms: Role of... Studies the role of phospholipase C in the regulation of insulin secretion via ATP-sensitive potassium channel independent mechanisms. Underexpression of i... Zawalich,S Walter,C Kathleen - 《American ...
The ATP generated during glycolysis (in the cytosol) and oxi dative phosphorylation (in the mitochondria) is respon sible for the closing of an ATP-sensitive potassium channel in the plasma membrane. This causes depolar isation of the cell and opening of a voltage-sensitive cal...
The high-affinity sulfonylurea receptor (SUR1) is, as a subunit of the ATP-sensitive potassium channel, an important regulator of insulin secretion in the ... T Hansen,SM Echwald,L Hansen,... - 《Diabetes》 被引量: 558发表: 1998年 The role of the body mass index and triglyceride level...