Abstract #234: Regular Insulin Administered with the V-Go Disposable Insulin Delivery Device in a Clinical Diabetes Setting: A Retrospective Analysis of Efficacy and Costdoi:10.1016/S1530-891X(20)44942-0David SuttonCharissa HigdonMark Carmon
In 1923, the first insulin commercially available was in concentrations of 3–5 units/mL. With the advent of continual process improvements, concentrations of insulin formulations increased rapidly to 20 units/mL administered using a syringe designed with 20 division marks per mL, then to be follow...
Insulin can be administered via: ■ syringe; ■ insulin pen; ■ insulin pump; ■ jet injector. The current mode of administration of insulin is via subcutaneous injection by means of syringes. A summary of advantages and disadvantages of insulin delivery devices is given in Table 1.4. Table 1....
A randomized, 16-week, open-label, parallel design study of pediatric patients with type 1 diabetes (n=298) aged 4-18 years compared two subcutaneous infusion regimens administered via an external insulin pump: NOVOLOG (n=198) or insulin lispro (n=100). These two treatments resulted in com...
say, the jet injectors are a solution for patients with needle phobia [127]. Recent safety and feasibility studies have evaluated the treatment efficiency and pharmacokinetic and pharmacodynamic (PK-PD) profiles of the insulin administered by the new-generation jet injectors [127,128]....
When administered intravenously, another insulin lispro product, 100 units/mL demonstrated dose-dependent clearance, with a mean clearance of 21.0 mL/min/kg (0.1 unit/kg dose), and 9.6 mL/min/kg (0.2 unit/kg dose). Another insulin lispro product, 100 units/mL, demonstrated a mean t1/2 of...
These advanced insulin pens have the capability to log details of insulin doses, such as the timing and quantity of insulin administered. The collected data can then be synchronized with a compatible application, allowing both individuals with diabetes and their healthcare providers to review the ...
24 These ultra-rapid-acting insulin formulations provided better post-prandial glycemic control over the rapid-acting insulin analogs, when administered before or within 20 min of a meal.24,25 The strategies adopted for rapid-acting insulin analogs are depicted in Figure 1B. This shorter duration ...
On days 1–7 participants took variable doses of prandial insulin (insulin glulisine, administered in disposable pens for SC injection) at mealtimes as needed, in addition to the fixed daily basal insulin doses. The basal insulin dose on day 8 of each treatment period was given in fasting ...
Insulin is usually administered by injection under the skin (subcutaneously). The subcutaneous tissue of the abdomen is preferred because absorption of the insulin is more consistent from this location than subcutaneous tissues in other locations. When insulin was first discovered and made available for...