Although the insular cortex (IC) has been reported to be a key brain region in mediating emotional and motivational alterations induced by drug consumption and withdrawal, the role of IC in anxiety related to protracted abstinence remains elusive. In this study, we found that: (1) anxiety-like...
Allen Mouse Brain Atlas, mouse.brain-map.org and atlas.brain-map.org. c Quantification of labeled monosynaptic inputs to IC projectors. IC-NAc projectors, n = 3 mice; IC-CeA projectors, n = 4 mice. SS somatosensory area, MO somatomotor area, OFC orbitofrontal cortex, PERI peri...
Biology of Sex Differences (2024) 15:29 https://doi.org/10.1186/s13293-024-00593-4 Biology of Sex Differences RESEARCH Open Access Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex Daniela Iezzi1,2, Alba Cáceres‑Rodríguez1,2...
Photomicrographs showing examples of cytoarchitecture of the insular cortex in human (a), macaque (b), cat (c), and mouse (d).aFrontoinsular cortex, FI;bposterior insular cortex, PI;c,danterior insular cortex, AI. Cortical layers are indicated by Roman numerals.Clclaustrum,CPcaudate-putamen...
K. Sensory integration in mouse insular cortex reflects GABA circuit maturation. Neuron 83, 894–905 (2014). Article CAS Google Scholar Livneh, Y. et al. Homeostatic circuits selectively gate food cue responses in insular cortex. Nature 546, 611–616 (2017). Article CAS Google Scholar ...
Abnormal behavior and neurotransmissions of tenascin gene knockout mouse 1996, Biochemical and Biophysical Research Communications Show abstract Rostral Agranular Insular Cortex and Pain Areas of the Central Nervous System: A Tract-Tracing Study in the Rat 2004, Journal of Comparative Neurology Dopamine ...
The half-life of Torin 1 is about 4min (human/mouse microsome). Recently it is reported that Torin 1 can intervene mTOR signaling in insular cortex to alleviate neuropathic pain [235]. However, although Torin 1 has a strong inhibitory effect on mTOR, its poor stability and low oral bioavai...
(GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325...
The insular cortex (IC) is associated with important functions linked with pain and emotions. According to recent reports, neural plasticity in the brain including the IC can be induced by nerve injury and may contribute to chronic pain. Continuous active kinase, protein kinase Mζ (PKMζ), ha...
The insular cortex (IC) is an important forebrain structure involved in pain perception and taste memory formation. Using a 64-channel multi-electrode array system, we recently identified and characterized two major forms of synaptic plasticity in the adult mouse IC: long-term potentiation (LTP) ...