“After more than 20 years of research and a progressive understanding of the role of orexin in sleep-wake balance and of the potential of orexin receptor antagonism, we designed daridorexant to help address several issues people with insomnia face. Daridorexant properties include a potent inhibit...
Our results also show that insomnia may be associated with an increased risk of developing a chronic medical condition. These results are consistent with prior studies demonstrating an association between insomnia and chronic disease, such as upper airway disease, in children5. There is evidence that...
Common daytime symptoms of insomnia are fatigue, despondency or impatience, overall malaise, and cognitive impairment. The disease is usually associated with high blood pressure, diabetes, and depression. Medications that target gamma-aminobutyric acid type-A (GABA-A) and serotonin, histamine, ormelato...
To begin to address this lack of evidence, there have been a few clinical trials conducted to assess the efficacy and safety of cognitive behavioral therapy for insomnia in patients with chronic pain. These studies also assessed if improvements in sleep would also be associated with improvements in...