Inhibition of INSM1 results in decreased formation of glucagon and insulin positive cells. The gene encoding INSM1 is directlyregulated by Neurogenin 3 which binds chromatin in the INSM1 promoterregion and induces transcription.BreslinNotkinsM.S...
【Abstract 】This article presents a 34-year-old woman with cervical small cell neuroendocrine carcinoma.Micro-scopic examination revealed diffuse distribution of small round cells,with scant cytoplasm,deeply stained nuclei,and in-conspicuous nucleoli.Immunohistochemistry demonstrated positive results for ...
INSM1-positive mimics comprised a small subset of chordoma (1 of 10), soft tissue myoepithelioma (1 of 20), ossifying fibromyxoid tumor (3 of 10), and Ewing sarcoma (3 of 10), among other tumor types. The majority of these cases showed labeling inAkihiko...
Applications:Positive Control; Immunogen; SDS-PAGE; WB. (May be suitable for use in other assays to be determined by the end user.) Predicted isoelectric point:6.9 Predicted Molecular Mass: 45.9kDa Accurate Molecular Mass: 46kDa as determined by SDS-PAGE reducing conditions. [ USAGE ] Reconstit...
IHC positive control: Human esophagus cancer and Human breast cancer IHC Recommend dilution: 50-300 上一条ATCCBAA-793标准菌株下一条ATCC367基因组DNA标准菌株 一抗相关信息 查看更多信息 ATCC8321标准菌株 ATCC9239标准菌株 ATCC9689标准菌株 ATCC10722标准菌株 ...
Applications:Positive Control; Immunogen; SDS-PAGE; WB. (May be suitable for use in other assays to be determined by the end user.) Predicted isoelectric point:6.9 Predicted Molecular Mass: 45.9kDa Accurate Molecular Mass: 46kDa as determined by SDS-PAGE reducing conditions. [ USAGE ] Reconstit...
Insulinoma Associated-1（IA-1/INSM1）是一类含有锌指结构的转录因子，已有研究表明在神经母细胞瘤、宫颈小细胞癌等多种神经内分泌肿瘤都有异常表达[2-3]。本实验旨在通过免疫组织化学方法检测INSM1蛋白在SCLC组织中的表达水平，分析INSM1作为诊断SCLC标志物的可行性。1 材料与方法1.1 材料 收集大庆市人民医院病理...
To increase sensitivity, neuroendocrine markers are routinely ordered as panels of multiple immunostains where any single positive marker is regarded as sufficient evidence of neuroendocrine differentiation. Insulinoma-associated protein 1 (INSM1) is a well-validated transcription factor of neuroendocrine ...
By definition, all large cell neuroendocrine carcinomas had neuroendocrine morphologic features on H&E, and were positive for at least one neuroendocrine marker. Immunohistochemistry Details of the antibodies used are provided in Table 2. INSM1 was diluted 1:250 using SignalStain® Diluent (Cell ...
CD44-negative QGP1-TGLΔInsm1 cells gave rise to spheroid colonies, whereas CD44-positive QGP1-TGLΔInsm1 cells produced colonies with invasive morphologies (Fig. 5e). These data indicate that loss of Insm1 can produce more invasive, stem-like cells. Fig. 5: Loss of Insm1 expression ...