Given their physiological similarities to humans, pigs are increasingly used as model organisms in human-oriented biomedical studies. Additionally, their value to animal agriculture across the globe has led to the development of numerous studies to inves
Current treatment strategies for cancer, especially advanced cancer, are limited and unsatisfactory. One of the most substantial advances in cancer therapy, in the last decades, was the discovery of a new layer of immunotherapy approach, immune checkpoint inhibitors (ICIs), which can specifically acti...
Pharmacoepigenetics: Novel Mechanistic Insights in Drug Discovery and Development Targeting Chromatin-Modifying Enzymes - ScienceDirectdoi:10.1007/978-1-4614-7931-4_13Ravikumar VilwanathanAnusha ChidambaramRamesh Kumar ChidambaramPharmacoepigenetics
In this narrative review, we performed literature search in databases PubMed, Web of Science and Embase by using keywords “ageing”, “Alzhermer's disease” and each of the factors such as “genomic instability”. To describe the concept of implementation, Medical Subject Heading (MeSH) terms ...
Camilo V, Pacheco MB, Moreira-Silva F, Outeiro-Pinho G, Gaspar VM, Mano JF, Marques CJ, Henrique R, Jerónimo C. Novel Insights on the Role of Epigenetics in Androgen Receptor’s Expression in Prostate Cancer.Biomolecules. 2023; 13(10):1526. https://doi.org/10.3390/biom13101526 ...
HOX genes; adipose tissue dysfunction; metabolic diseases; obesity and type 2 diabetes; hypertrophic obesity; adipogenesis; fat mass distribution; inflammation; epigenetics; DNA methylation; epigenetic biomarker; targeted therapy1. Introduction HOX genes are the largest and most extensively studied members ...