The mechanistic underpinnings of this inside-out Ca2 þ signalling were largely undefined. By taking advantage of a unique gain-of-function mutation within the STIM1 transmembrane domain (STIM1-TM), here we show that local rearrangement, rather than alteration in the oligomeric state of STIM1-...
Second, to detect nano-to-microsecond motions, we carried out atomistic molecular dynamics (MD) simulations on OLFWT(Fig.6b, Supplementary Fig.10). The simulations reveal relatively limited motions over a 10-μs trajectory, similar to previous results obtained carried out at higher simulation temp...
1. 路線表發現發送詞條到目的地IP地址。 [translate] a4. The packet is going from an inside to an outside network. The router looks up its NAT table for necessary translations. 4. 小包從裡面去外部網絡。 路由器為必要的翻譯查找它的NAT桌。 [translate] ...
Every June, Pride Month is recognized throughout the U.S. in honor of the 1969 Stonewall Uprising, routinely marked as the inception of the Gay Liberation Movement. To honor this occasion, Sony Music Group (SMG)—with the help of our Talent Advisory ...
A negative trade review cost the film a theatrical release. The producers, he said, “kind of left me alone,” adding, “It was a great experience for me because I really felt I had stepped out and done something.” It’s the same feeling he had writing his first novel,Stars Screaming...
ryan said it was daley who suggested he reach out to grazer—cofounder of imagine with ron howard —to pick his brain about which agents might best help the post expand into film and television. “we just hit it off from the very beginning when i explained what we were trying to do,...
“Oh yeah, these are my people. We’re out of the same background, the same occupation. Yeah, I felt a very strong affinity with these women. I really found myself as I was writing about them feeling like I knew them and wishing I could actually have known them. I guess I felt ...
I had a very negative attitude toward him because he was pushing the idea of limited nuclear war as a substitute not only for all-out war but also for no nuclear war. He thought that if we forewent the possibility of nuclear weapons the world would be taken over by stronger nations; an...
So throughCuttingswe were able to deliver that, but in a sensitive, nice, light kind of way. But there are elements in our play that will rip your heart out. And that will make you understand and make you be aware that it’s okay to talk about it [such difficult things]. And it’...
The portal crown affords a reference point for specifying the positions of gas clouds out along the portal axis. (We refer to inner surface of the gp1 dodecamer, minus the barrel of C-terminal domains, as the “crown” [Fig. 6F].) The spacing from the center of a gas cloud to the ...