Inositol-requiring enzyme 1 alpha (IRE1伪), the most conserved endoplasmic reticulum (ER) stress sensor, has been implicated in the pathophysiology of liver injury. Activated IRE1伪 endoribonuclease (RNase) can splice X-box binding protein 1 (XBP1) mRNA to produce the sXBP1 transcription factor...
ER stress activates the cellular unfolded protein response (UPR) regulated by three ER-resident transmembrane signal transducers, inositol-requiring enzyme 1 (IRE1), protein kinase RNA-like endoplasmic reticulum kinase (PERK), and activating transcription factor 6 (ATF6) (22, 23). IRE1 is the ...
Inositol Requiring Enzyme 1 alpha (IRE) Regulates Granulosa Cell Steroidogenesis Independent of its Role in the Unfolded Protein ResponseInositol Requiring Enzyme 1 alpha (IRE) Regulates Granulosa Cell Steroidogenesis Independent of its Role in the Unfolded Protein ResponseLarry Denner...
alpha kinase 3, protein-kinase and site-specific endoribonuclease/inositol-requiring enzyme 1, binding immunoglobulin protein, and C/EBP homologous transcription... J Cai,L Su,W Luo - 《Current Topics in Nutraceutical Research》 被引量: 0发表: 2022年 加载更多来源...
(Fig.3b). This may be explained by a more potent induction of calcification in the CPP-induced assay, requiring higher (OEG2)2-IP4 concentration to counteract the procalcific environment. In the CaP assay, low inhibitor concentration may be sufficient to inhibit crystal nucleation, whereas for ...
The low abundance of inositol polyphosphate 1-phosphatase in tissues has precluded structural studies requiring large quantities of enzyme. We used recombinant Baculovirus harboring the cDNA of bovine inositol polyphosphate 1-phosphatase to infect Spodoptera frugiperda (Sf9) insect cells. Recombinant protein...
Mechanism of inositol-requiring enzyme 1-alpha inhibition in endoplasmic reticulum stress and apoptosis in ovarian cancer cellsIRE1αER stressApoptosisOvarian cancerIRE1伪 endonuclease is a key regulator of endoplasmic reticulum (ER) stress that controls cell survival/apoptosis in cancers. Inhibition of ...
Inositol‐requiring enzyme 1 alpha (IRE1α) regulates astrocyte metabolic and inflammatory phenotypes: Implications in (METH)amphetamine use disorder and HIV‐associated neurocognitive disordersHuman immunodeficiency virus 1 (HIV‐1) invades the central nervous system (CNS) early...
B-cell lymphoma 2 (BCL2)-associated X protein (Bax) inhibitor-1 (BI-1), a negative regulator of the ER stress sensor, inositol-requiring enzyme 1 alpha (IRE1α), has yet to be explored in NAFLD as a hepatoprotective agent. We hypothesized that the genetic ablation of BI-1 would ...
GRINA glutamate receptor, ionotropic NMDA-associated protein 1 GRP78/BiP glucose-regulated protein 78/immunoglobulin heavy chain-binding protein IICR IP3-induced Ca2 + release IP3 inositol 1,4,5-trisphosphate IP3R inositol 1,4,5-trisphosphate receptor IRE1α inositol-requiring enzyme 1α MAM mitoc...