Inositol hexaphosphate (IP6, InsP6) is a polyphosphorylated carbohydrate with diverse signaling properties. IP6 is plentiful in organisms as diverse as yeast, actinobacteria, mammals and plants. In the plant kingdom, IP6 accumulates during seed development; during germination it is broken down into...
In 2016, Dr. Mariano Bizzarri reviewed inositol and inositol hexaphosphate (InsP6) as broad spectrum anticancer agents writing: Further investigation demonstrated that InsP6 [inositol-6-phosphate] had unequivocal apoptotic effects on both solid and haematogenous tumors. Indeed, InsP6 has been shown to...
Inositol Hexaphosphate -Introduction Pharmacological effect: It can promote the release of oxygen in oxyhemoglobin, improve the function of red blood cells, and prolong the survival time of red blood cells. Phytic acid itself is a beneficial nutrient to the human body. The hydrolysates of phytic ac...
Microbiol 144:1565–1573 Zhang Z, Song Y, Wang XL (2005) Inositol hexaphosphate-induced enhancement of natural killer cell activity correlates with suppression of colon carcinogenesis in rats. World J Gastroenterol 11:5044–5046]]>PhytaseProtein tyrosine phosphatase...
The bioavailability ofmyo-inositol fromphytic acid(inositol hexaphosphate) is very limited and depends on a variety of factors such asphytatesolubility and the presence of minerals, plantphytases, microbial intestinal phytases, delivered phytases and food processing (EFSA, 2016). ...
Ingram SW, Stratemann SA, Barnes LD (1999) Schizosaccharomyces pombe aps1, a diadenosine 5′, 5′ “-p1, p6-hexaphosphate hydrolase that is a member of the nudix (mutt) family of hydrolases: cloning of the gene and characterization of the purified enzyme. Biochemistry 38:3649–3655 ...
The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein J. Biol. Chem., 274 (31) (1999), pp. 21735-21740 View PDFView articl...
The crystal structure of the HDAC1:MTA1 complex bound to a novel peptide-based inhibitor and to inositol hexaphosphate suggests a molecular basis of substrate recognition, and an entropically driven allosteric mechanism of activation. 1 Henry Wellcome Laboratories of Structural Biology, Department of ...
Inositol hexaphosphates (InsP6) are ubiquitous in eukaryotes and regulates a plethora of cellular functions. Here the authors identify a set of receptor-like cytoplasmic kinases that work in concert with 14-3-3- proteins to regulate InsP6 synthesis and accumulation and Pi homeostasis in Arabidopsis...
Inositol hexaphosphate (InsP6 or phytic acid) has been shown to have antineoplastic action in in vivo models of colon carcinogenesis. We therefore investigated its effect on proliferation and differentiation of the human colon cancer cell line HT-29 in vitro. Proliferation was evaluated by neutral ...