In this review, we focus on the innate immune stimulation by mRNA-iLNP vaccines, discuss recent insights gained from descriptive and hypothesis-driven studies on the dynamics and activation of innate immune cell
1 | Mechanisms of immunogenicity of and reactogenicity to LNP-mRNA vaccines. In the lymph nodes (LNs), modified RNA sensed by MDA-5 results in the production of type I interferons (IFNs). Type I interferons induce antigen-specific CD8+ T cell responses. LNPs can activate innate immune ...
1 | Mechanisms of immunogenicity of and reactogenicity to LNP-mRNA vaccines. In the lymph nodes (LNs), modified RNA sensed by MDA-5 results in the production of type I interferons (IFNs). Type I interferons induce antigen-specific CD8+ T cell responses. LNPs can activate innate immune ...
To decipher this Janus effect, we describe the different innate response mechanisms triggered by mRNA molecules and how each element from the 5' cap to the poly-A tail interferes with innate/adaptive immune responses. Then, we emphasize the importance of some critical steps such as production, ...
The novel vaccines of the present invention combine both of the signals necessary to activate native T-cells - specific antigen and the co-stimulatory signal - leading to a robust and specific T-cell immune response.MEDZHITOV RUSLAN M. PH. D....
There is compelling evidence that glial-immune interactions contribute to the progression of neurodegenerative diseases. The adaptive immune response has been implicated in disease processes of amyotrophic lateral sclerosis (ALS), but it remains unknown
mRNA vaccines encapsulated in LNPs were also found to induce a high magnitude of germinal center B (GC B) cell and follicular helper T cells (TFH) responses after a single immunization5,6,7,8. Several studies have analyzed immune responses to the BNT162b2 vaccine in humans and revealed ...
this review encapsulates the employment of combinational therapies those involve PD-1/PD-L1 blockade alongside the activation of innate immunity and explores the underlying cellular mechanisms, aiming to harnessing innate immune responses to induce long-lasting tumor control for CRC patients who received ...
Mechanisms of mtDNA release and its effects on innate immune response. The release of mtDNA from mitochondria into the cytosol is triggered by different factors, including radiation exposure, microbial infection, inflammatory conditions, toxic substances or drugs, and gene mutation or deletion. Under ap...
the innate mechanisms of 3M-052 have not been fully characterized. Here, we perform flow cytometry, single cell RNA-seq and ATAC-seq to profile the kinetics, transcriptomics and epigenomics of innate immune cells in murine draining lymph nodes following 3M-052-Alum/Ovalbumin immunization. We find...