Influence of the injection site on bioavailability in dogs was investigated for injections with ampicillin anhydrate or amoxycillin trihydrate suspensions. Firstly, pharmacokinetic parameters were calculated after IV administration of the sodium salts. Then the dogs were injected in the neck (SC), in ...
One way is to ask your doctor or read the instructions on the medications pamphlet or labels, it should be in bold letters: “FOR SUBCUTANEOUS DELIVERY“ or “FOR (IM) INTRAMUSCULAR DELIVERY.” This means the following: Injection sites should be identified as Intramuscular or subcutaneous. ...
Tissue damage at the injection site has been described after intramuscular injection of antibiotics, chemotherapeutics, vitamins, lidocaine, diazepam and digoxin in dogs, swine, cows, sheep and hens.The damage caused by substances commonly used in drug vehicles has also been examined and compared with...
No testicular abnormalities were seen in dogs given 50 mg/kg/day, IV for 1 month (1 to 3 times human levels) or in dogs given 60 mg/kg/day orally for 1 year (the same as human levels). Testicular atrophy and aspermatogenesis were observed in rats and dogs at higher dose levels. ...
In September, Philadelphia City Council voted to ban what are known as safe injection sites, a major blow for advocates who say these sites could help prevent deaths in the region. On Thursday night, CBS Philadelphia talked with those for and against the sites, including someone experiencing add...
Studies of levetiracetam in juvenile rats (dosing from day 4 through day 52 of age) and dogs (dosing from week 3 through week 7 of age) at doses of up to 1800 mg/kg/day (approximately 7 and 24 times, respectively, the maximum recommended pediatric dose of 60 mg/kg/day on a mg/m...
Antihistamines appear to compete with histamine for cell receptor sites on effector cells. Benadryl in the injectable form has a rapid onset of action. Diphenhydramine hydrochloride is widely distributed throughout the body, including the CNS. A portion of the drug is excreted unchanged in the ...
Ceftizoxime had no effect on fertility when administered subcutaneously to rats at daily doses of up to 1000 mg/kg/day, approximately two times the maximum human daily dose on an mg/M2 basis. Ceftizoxime produced no histological changes in the sexual organs of male and female dogs when given...
Pharmacokinetic parameters used are based on plasma) concentration data for phenobarbitone in dogs,(adapted from Klockowski, P.M., and Levy, G.: J. Pharm. Sci. 76, 516–520, 1987.) Experimental data on the relationship between the rate of intravenous infusion and the threshold dose for a...
Concretions consisting of the precipitated calcium salt of ceftriaxone have been found in the gallbladder bile of dogs and baboons treated with ceftriaxone. These appeared as gritty sediment in dogs that received 100 mg/kg/day for 4 weeks. A similar phenomenon has been observed in baboons but on...