Such pharmaceutical advances, however, have not been available in the anti-diabetic segment so far. This is because the challenges of producing and combining biologically engineered molecules, such as insulin and GLP1RA, are infinitely greater than those utilizing synthetic chemical compounds. In this...
ArticleCASPubMedGoogle Scholar Fujita Y, Doi Y, Hamano T, Hatazaki M, Umayahara Y, Isaka Y, Tsubakihara Y. Low erythropoietin levels predict faster renal function decline in diabetic patients with anemia: a prospective cohort study. Sci Rep. 2019;9(1):14871. ...
Patients were randomly assigned to receive BYDUREON 2 mg given subcutaneously once every 7 days (weekly) or liraglutide uptitrated from 0.6 mg/day to 1.2 mg/day, then 1.8 mg/day in addition to their existing oral antidiabetic therapy. Each titration was to be completed after at least one ...
In some cases, hyperglycemia has resolved when the atypical antipsychotic was discontinued; however, some patients required continuation of anti-diabetic treatment despite discontinuation of the suspect drug. Pooled data from the four placebo-controlled (one 9-week and three 13-week), fixed-dose ...
we show that a subcutaneous depot formed after a single injection of GLP1 recombinantly fused to a thermosensitive elastin-like polypeptide results in zero-order release kinetics and circulation times of up to 10 days in mice and 17 days in monkeys. The optimized pharmacokinetics lead to 10 days...
We report here an injectable, self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic wound regeneration. The hydrogel was prepared by coordinative cross-linking of multi-arm thiolated polyethylene glycol (SH-PEG) wit
amphotericin B injection, potassium-depleting agents, antibiotics, anticholinesterases, anticoagulants, antidiabetics, antitubercular drugs, barbiturates, phenytoin, carbamazepine, rifampin, ketoconazole, cholestyramine, cyclosporine, digitalis glycosides, ...
A diabetic mice wound skin model was used to assess the effect of different hydrogels on the therapeutic effect of hADMSC 3D encapsulations. Diabetes was induced in CD-1 male mice by five daily injections of streptozotocin (STZ). Ten days after the last STZ injection, 8 mm round full-thickn...
This project aims to combine the properties of hydrogels based on chitosan (CHT) and the polymer of β cyclodextrin (PCD) for local delivery of cinnamaldehyde (CN) in diabetic foot ulcers. This work consisted of the development and characterisation of the hydrogel, the evaluation of the CN ...
Capsaicin 8% Patch Versus Oral Neuropathic Pain Medications for the Treatment of Painful Diabetic Peripheral Neuropathy: A Systematic Literature Review and Network Meta-analysis. Clin. Ther. 2017, 39, 787–803.e18. [Google Scholar] [CrossRef] [PubMed] [Green Version] O’Neill, J.; Brock, C...