Synonyms Initiation phase of translation ; Protein synthesis initiation Definition The process by which the ribosome binds methionyl tRNA i Met (Met-tRNA i Met ; in bacteria, formyl Met-tRNA f Met or fMet-tRNA f Met ) base-paired to the mRNA start codon in the peptidyl-tRNA binding (P)...
Translation is a highly regulated process that is perturbed in human cancers, often through activation of the PI3K/mTOR pathway which impacts directly on the ribosome recruitment phase of translation initiation. While significant research has focused on "drugging" components of the PI3K/mTOR network, ...
of its HCFCs Phase-out Management Plan, specifically,initiationofstrategic prioritization in different sectors for HCFC [...] multilateralfund.org multilateralfund.org 执行委员会还指出,在《国家方案》 的框架内,波斯尼亚和黑塞哥维那在编制氟氯烃淘汰管理计划上取得了长足进步,具体而言,启动各行业氟氯烃消费...
Elevated protein synthesis is an important feature of many cancer cells and often arises as a consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F), the key regulator of the mRNA-ribosome recruitment phase of translation initiation. In many cellular ...
Because the pseudoknot in lines C and D begins 13-nt downstream from the AUG codon, assembly of an initiation complex is not impeded; the pseudoknot thus positioned is a barrier to only the elongation phase of translation. Deletion of 6 nt (underlined in line D) moves the pseudoknot closer...
Protein synthesis is a fundamental biological mechanism bringing the DNA-encoded genetic information into life by its translation into molecular effectors - proteins. The initiation phase of translation is one of the key points of gene regulation in eukaryotes, playing a role in processes from neuronal...
Eukaryotic ribosomes are widely presumed to scan mRNA for the AUG codon to initiate translation in a strictly 5′–3′ movement (i.e., strictly unidirectional scanning model), so that ribosomes initiate translation exclusively at the 5′ proximal AUG cod
1. The first stage of tumor induction by a carcinogen; subtle alteration of cells by exposure to a carcinogenic agent so that they are likely to form a tumor on subsequent exposure to a promoting agent (promotion). 2. Starting point of replication or translation in macromolecule biosynthesis...
I think twice about this project, project initiation phase I will be responsible for follow up. 翻译结果4复制译文编辑译文朗读译文返回顶部 I consider this project 3, the project start-up period will be for me to follow up. 翻译结果5复制译文编辑译文朗读译文返回顶部 This project I consider over...
1. A rapid method for determining the use of different translation initiation sites of a nucleic acid encoding a protein, said method comprising: a) providing said nucleic acid, wherein the nucleic acid comprises a first and second stop codon, said first and second stop codon being seperate an...