Antiarrhythmic drugs (AADs) are traditionally considered to be the preferred initial therapy for the maintenance of sinus rhythm however, these medications have modest efficacy and significant adverse effects. Recent clinical trials have evaluated the role of catheter ablation as the initial therapeutic ...
A total of 990 patients with NSTE-ACS, treated with aspirin and standard therapy for ACS, were randomized in a 1:1:1 double-blind fashion to receive either twice-daily AZD6140 90 mg, AZD6140 180 mg, or clopidogrel 300-mg loading dose plus 75 mg once daily for up to 12 weeks. Result...
Based on this, copolymers modified with CP groups have also been applied in drug delivery systems for enhanced cellular internalization [19,20]. Furthermore, CP modified surface showed resistance against protein adsorption due to their zwitterionic properties [21]. In a word, the introduction of ...
The present study examined past-month pain severity in relation to e-cigarette dependence, perceived barriers for quitting e-cigarettes, and beliefs about risks associated with using e-cigarettes. Participants were 322 e-cigarette users from the United States (60.2% female, Mage= 36.78 years, SD...
drug is present in animal milk, it is likely that the drug will be present in human milk. The developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for clopidogrel and any potential adverse effects on the breastfed infant from clopidogrel or ...
For example the initial rate activity of enzymes such as kinases, phosphatases, proteases, or sulfatases, which are important drug targets13–16, cannot be studied using natural substrates. To over- come limitations of the colorimetric assays various label-free methods for fast measurement of ...
The objectives of this analysis are to evaluate the impact on overall survival, disease progression and TEEs of different Hb intervention and target levels for epoetin-β therapy and in particular, to explore the safety of epoetin-β with respect to its effects on overall survival and disease pro...
Two well-known APIs were selected for our solvent screening strategies: acetaminophen (4-acetamidophenol) and racemic (±)-ibuprofen (α-methyl-4- [isobutyl] phenylacetic acid) (see Figure 1), because of their worldwide commercial values in analgesic and antipyretic therapy, th...
drug candidates, is very limited. For example the initial rate activity of enzymes such as kinases, phosphatases, proteases, or sulfatases, which are important drug targets13,14,15,16, cannot be studied using natural substrates. To overcome limitations of the colorimetric assays various label-free...
biodistribution assay in induced animal models with TNBC showed that although there was a high capture by intestine (>30%), the DDS developed had a high tumor uptake (5%) and with great in vivo imaging properties, corroborating the possibility of use of this DDS as an imaging drug for TNBC...