The present Disclosure provides compounds that are inhibitors of Tyrosine Kinases, particularly inhibitors of the tyrosine kinase Bruton (BTK), and thereforeThey are useful for the treatment of diseases that can be treated through inhibition of BTK such as cancer, autoimmune diseases, inflammatory and...
新型酪氨酸激酶抑制剂 Novel Tyrosine Kinase Inhibitors本发明提供调节酪氨酸激酶活性的式(I)的化合物,或其立体异构体,互变异构体,盐,水合物或前药,包含所述化合物的组合物和其使用方法. The present invention provides a compound to modulate the activity of tyrosine of formula (I) kinase, or a ...
The epidermal growth factor receptor (EGFR), also called HER1, belongs to ErbB family which is composed of four structure-related RTKs: HER1-4. EGFR is a transmembrane glycoprotein with tyrosine kinase activity in its endo-domain. The activation of EGFR can initiate several crucial signal casca...
adampen 挫伤[translate] aa return path 一条返回途径[translate] aa set of keys 一套钥匙[translate] aAren't you 不是您[translate] aThe girl we loved those years 正在翻译,请等待...[translate] atyrosine kinase inhibitors 酚基乙氨酸激酶抗化剂[translate]...
PROTEIN TYROSINE KINASE ENZYME INHIBITORS 青云英语翻译 请在下面的文本框内输入文字,然后点击开始翻译按钮进行翻译,如果您看不到结果,请重新翻译! 翻译结果1翻译结果2翻译结果3翻译结果4翻译结果5 翻译结果1复制译文编辑译文朗读译文返回顶部 蛋白酪氨酸激酶酶抑制剂...
The availability of 3 generations of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) with different pharmacologic characteristics and clinical profiles has provided oncologists with a potentially confusing choice for the treatment of EGFR mutation-positive non–small-cell lung canc...
et al. Cardiac toxicity of targeted therapies used in the treatment for solid tumours: a review. Cardiovasc. Toxicol. 12, 191–207 (2012). Article CAS PubMed Google Scholar Chu, T. F. et al. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet 370, 2011–2019 (2007...
The clinical benefit of tyrosine kinase inhibitors (TKIs)-based systemic therapy for advanced hepatocellular carcinoma (HCC) is limited due to drug resistance. Here, we uncover that lipid metabolism reprogramming mediated by unconventional prefoldin RPB5
Role of Tyrosine Kinase Inhibitors in Cancer Therapy Cancer chemotherapy has been one of the major medical advances in the last few decades. However, the drugs used for this therapy have a narrow therapeutic ... Arora,A - 《Journal of Pharmacology & Experimental Therapeutics》 被引量: 1332发表...
专利名称：Inhibitors of protein tyrosine kinase activity 发明人：Michael Mannion,Stephane Raeppel,Stephen William Claridge,Frederic Gaudette,Lijie Zhan,Ljubomir Isakovic,Oscar Mario Saavedra,Tetsuyuki Uno,Masashi Kishida,Arkadii Vaisburg 申请号：US12964289 申请日：20101209 公开号：US08759522B2 公开日：2014...