Inhibitor of Cyclin-Dependent KinaseAntonio BrunettiRuslan NovosyadlyyDerek LeRoithBoaz HirshbergMichael Z. GilcreaseAngela MärtenWilliam L. FarrarTaosheng ChenThomas RiedKenneth W. Yip
Two regions, FDF (residues 62–64) and GXY (residues 72 and 74), were identified within the β hairpin region of p27. Mutations within these regions essentially completely inhibited the binding totranslated cdk2 and cdk2/cyclin E complexes formedor. The p27GST-fusion protein of the point ...
Albert Einstein College ofMedicine, Bronx, NewYork 10461 [W.T., J.W.P.] Abstract The involvement ofcyclin-dependent kinase inhibitors indifferentiation remains unclear are the roles of cyclin-dependent kinase inhibitors restricted tocell cycle arrest oralso required for completion ofthe differentiation...
In this review, we summarized the current understanding with THZ1, a covalent inhibitor of cyclin-dependent kinase 7 (CDK7), which demonstrated promising anti-tumor activity against different cancer types. By introducing the anti-tumor behaviors and the potential targets for different cancers, this ...
产品名称:Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 ELISA Kit 检测范围:1.56-100 ng/mL 保存条件:2-8℃低温保存 保质期:6个月,所有试剂盒均提供批次。 试剂盒成分:酶标板,试剂,标准品等。 标本要求 1.标本采集后尽早进行提取,提取按相关文献进行,提取后应尽快进行实验。若不能马上进行试验,可...
Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) is a gene that, when hypermethylated, leads to the silencing of the cell cycle inhibitor p15 INK4B, resulting in uncontrolled cell cycle progression and cellular proliferation in Myelodysplastic Syndromes (MDS). ...
p27 is an inhibitor of cyclin dependent kinase involved in the regulation of the cell cycle. In this commentary we discuss the current knowledge on p27 in breast cancer and its significance in predicting the outcome. p27 protein levels are high in most cases of breast carcinomas, are correla...
By RT-PCR,the likely gene of cyclin-dependent kinase inhibitor in Oryza sativa(9311) was cloned and named OsICK1. 细胞周期蛋白依赖性激酶抑制剂(ICK)是一种能够影响细胞生长和发育的重要调控蛋白。 更多例句>> 3) cyclin-dependent-kinase inhibitor 细胞周期依赖性蛋白激酶抑制剂4...
2) cell circle related kinase inhibitor p27kip1 细胞周期依赖性激酶抑制剂p27kip1 3) cells 细胞 1. Advances in productivity enhancement of therapeutic recombinant proteins by modifying engineeredcells; 通过改造工程细胞提高重组蛋白类药物产量的研究进展 ...
周期素依赖激酶抑制剂对大鼠大脑中动脉缺血后海马迟发性神经元死亡的影响 Effects of cyclin-dependent kinase inhibitor on delayed neuronal death of hippocampus in rats after MCA occlusion;