For example, older adults, who suffer a disproportionate loss of executive control abilities relative to other cognitive functions, show difficulty inhibiting in the TNT paradigm. On the basis of this evidence, it seems that differences in memory suppression are at least partially attributable to ...
For example, Smad3 interacts preferentially with FoxO over Smad232. Interestingly, previous reports on Smad2/3 acetylation exclusively involved nuclear factors92,93 and the effect of Smad2/3 acetylation was correlated with promoter binding, transactivation activity, nuclear export or protein stability. ...
To attack those cells, inhibitors of signaling pathways that regulate self-renewal of normal somatic stem cells (for example, Wnt, Sonic Hedgehog and Notch pathways) have been proposed [6], but thus far the benefit of this strategy is limited. Obviously, specificity is a problem and it ...
One reason may be that factors upstream of the cascade have additional functions. This is indeed the case for some OAS, which have RNase L-independent antiviral activity [38•,39]. For example, upon dsRNA binding, the catalytically inactive human OASL can activate RIG-I. Even more surprising...
For example, several studies have shown that the combination of curcumin (major bioactive from turmeric) and piperine (major bioactive from black pepper) results in a synergistic inhibition of cancer cell growth. This is thought to occur because piperine enhances the bioavailability of curcumin, ...
To attack those cells, inhibitors of signaling pathways that regulate self-renewal of normal somatic stem cells (for example, Wnt, Sonic Hedgehog and Notch pathways) have been proposed [6], but thus far the benefit of this strategy is limited. Obviously, specificity is a problem and it ...
defense against pathogens but also in sensing internal harmful molecules such as mitochondrial peptides, f-MLKLIV, serum amyloid A, or prion protein [45,47]. One important characteristic of FPRs is that they can be activated by both, pro- and anti-inflammatory ligands. For example, the ...
However, disturbances in this "defense machinery" contribute to the pathogenesis of various diseases. The role of complement in various inflammatory disorders is multifaceted; for example, the activation of complement can significantly contribute to inflammation-mediated tissue damage, whereas inherited or ...
Here we report the first example of an Acr encoded by the rudivirus SIRV2 that inhibits CRISPR-Cas type III immunity. We hypothesize that SIRV2 encodes inhibitors of type I-A and III-B CRISPR-Cas systems in addition to type I-D (AcrID1) (He et al., 2018), given its infectivity in...
For example, using hypofractionated radiotherapy can boost anti-tumor cells, while attenuating immunosuppressive cells. Furthermore, the combination of it with immunotherapy drugs such as immune checkpoint blockers has shown interesting results in pre-clinical studies and also clinical trial studies [8,9...