falciparum dihydropteroate synthetase (dhps) gene that confer resistance to the anti-malarial sulphadoxine, and are a useful marker for the combination of alleles in dhfr and dhps that is highly correlated with resistance to sulphadoxine-pyrimethamine (SP). The aim of this study was to ...
45 First, they note that in their estimation, ∼50% of patients with high suspicion for an inherited thrombocytopenia will not have a known, identifiable underlying cause. Of those families where a more precise genetic diagnosis is made, the combination of features discussed above plus medical ...
Studies at the DNA level have shown that about half of the null alleles are due to deletions involving C4A and 21-OHA, C4B and 21-OHA or C4B and 21-OHB. Larger deletions including both C4A and C4B genes have never been observed. Partial C4 deficiency may be observed in combination with...
Together, these results clearly illustrate the power and importance of the combination of genotype and phenotype in the molecular diagnosis of heterogeneous diseases. For the first time, our study links mutations in the AHI1 gene to nonsyndromic RP. AHI1 mutations were first observed in patients ...
(Craddock et al, 2007; McClellan et al, 2007) and environmental (Brown et al, 2000; Cannon et al, 2002; Cantor-Graae, 2007) hypotheses of schizophrenia help explain phenomena observed in patients; however, it is a combination of some, or all, of these factors that likely leads to ...
Therefore, it seems reasonable to conjecture that inexperienced migrants might be able to “gauge” a magnetic signal based on intensity, inclination or some combination of both [82]. Gauging magnetic declination seems less likely for naïve migrants, since it requires comparison of geographic and ...
VWF is virtually absent in patients with type 3 (1–2% of cases), and FVIII levels are usually very low. Most of these patients are homozy gous or compound heterozygous for null alleles in the VWF gene.16 The remaining 20–25% of patients have Type 2VWD, further divided into four...
Combination of biochanin A and temozolomide impairs tumor growth by modulating cell metabolism in glioblastoma multiforme. Anticancer Res. 39, 57–66 (2019). CAS PubMed Google Scholar Robins, H. I. et al. Molecular evolution of a glioblastoma controlled with tumor treating fields and concomitant...
Leveraging the strengths of longitudinal research in ADAD cohorts, the DIAN-OBS was formed to investigate this disease using a combination of neuroimaging and other biomarker sampling methods. The unique traits of ADAD allow the DIAN-OBS design to deliver adequate power for inferences to be made ...
An hGH haplotype represents the combination of presence or absence of variable restriction sites for Bgl II, Hinc II and I at 5 locations in a single 55 kb hGH gene cluster . We studied 3 Israeli families with LTD. Different haplotypes are indicated by capital letters A-D: .Eam.1lY I ...