The introduction of long-acting -agonists at low doses of inhaled corticosteroids can achieve improved asthma control, avoiding the need for higher doses of inhaled corticosteroids. When asthma is not controlled by a dose of inhaled corticosteroids equivalent to 500 g/day fluticasone propionate and ...
Since all inhaled steroids have to cross the vocal the different inhaled steroids is in their side effect profiles at cords to be active this is the most difficult side effect to overcome clinically equivalent doses. and it is not helped by gargling and spitting out after inhaler use. ...
It is not clear whether high doses of inhaled steroids have a greater sparing effect than low doses on the requirement for systemic steroids. In a randomis... S Hummel,L Lehtonen - 《Lancet》 被引量: 233发表: 1992年 Evaluation of salmeterol or montelukast as second-line therapy for asthm...
Dose-related systemic effects of β2-agonists occur at higher doses, for salbutamol (albuterol) >500μg. Fenoterol is a β2-agonist with higher intrinsic activity than salbutamol and produces greater systemic effects at higher than conventional doses on a μg equivalent basis, although even ...
Data suggest that budesonide and formoterol delivered via a metered-dose inhaler is therapeutically equivalent to the dry-powder inhaler based on morning PEF measured in patients aged 12 years or older with suboptimal asthma control while using inhaled corticosteroids alone.47 However, specific trials ...
Bioequivalent doses of budesonide and prednisone in moderate and severe asthma We determined the relative antiasthmatic and systemic glucocorticoid potencies of inhaled budesonide (BUD) versus morning-dose oral prednisone (PRED) in 34... H J.,Toogood,and,... - 《Journal of Allergy & Clinical...
Formoterol or salmeterol were most frequently added to low-dose ICS (200 to 400 g/day of beclomethasone (BDP) or equivalent) in 49% of the studies. The addition of a daily LABA to ICS reduced the risk of exacerbations requiring oral steroids by 23% from 15% to 11% (RR 0.77, 95% ...
In the studies in which patients were exposed to 60 mg or greater of beclomethasone or its equivalent for the duration of the trial, inhaled corticosteroids were effective in reducing the total sputum cell count (-0.68 units; 95% CI, -1.11 to -0.26). In contrast, trials with cumulative ...
Current evidence suggests that significant risk of such toxicity is not likely to be associated with the long-term use of the equivalent of 800 µg/d of beclomethasone in adults and 400 µg/d in children. If higher doses are used to obtain greater clinical benefit, the answers to ...
an increased risk of diabetes mellitus (HR=1.34; 95% CI=1.29–1.39) and of diabetes progression (HR=1.34; 95% CI=1.17–1.53).36 The risk increased in a dose-dependent manner and was highest in patients who received ICS doses equivalent to fluticasone doses of 1,000 μg/day or higher...