As such, HFA-BDP is likely to achieve equivalent efficacy to existing CFC-BDP formulations with lower doses and with reduced potential for local adverse effects.doi:10.1016/S0954-6111(98)90211-6C L LeachRespir MedLeach CL. Improved delivery of inhaled steroids to the large and small airways....
Since all inhaled steroids have to cross the vocal the different inhaled steroids is in their side effect profiles at cords to be active this is the most difficult side effect to overcome clinically equivalent doses. and it is not helped by gargling and spitting out after inhaler use. ...
1. Prescribed doses of inhaled steroids in Dutch children: too little or too much, for too short a time. [J] . Schirm E, de Vries TW, Tobi H, British Journal of Clinical Pharmacology . 2006,第4期 机译:在荷兰儿童中吸入类固醇的处方剂量:太少或太多,时间太短。 2. Annual increase in ...
Formoterol or salmeterol were most frequently added to low-dose ICS (200 to 400 g/day of beclomethasone (BDP) or equivalent) in 49% of the studies. The addition of a daily LABA to ICS reduced the risk of exacerbations requiring oral steroids by 23% from 15% to 11% (RR 0.77, 95% ...
Dose-related systemic effects of β 2 -agonists occur at higher doses, for salbutamol (albuterol) >500μg. Fenoterol is a β 2 -agonist with higher intrinsic activity than salbutamol and produces greater systemic effects at higher than conventional doses on a μg equivalent basis, although ...
Data suggest that budesonide and formoterol delivered via a metered-dose inhaler is therapeutically equivalent to the dry-powder inhaler based on morning PEF measured in patients aged 12 years or older with suboptimal asthma control while using inhaled corticosteroids alone.47 However, specific trials ...
question whether in preschool children with asthma or wheezing the use of intermittent rather than ICS daily therapy might be more effective and less expensive. The Panel stated that proofs were insufficient to confirm that the intermittent use is better, worse or equivalent to daily administration ...
current use of ICS was associated with an increase in the rate ratio (RR) of pneumonia of 1.69, which was dose dependent, ranging from an RR of 1.24 for the lower doses to an RR of 1.86 with the highest doses of ICS (equivalent to fluticasone propionate 1,000 µg/day or more)....
Airway selectivity: an update of pharmacokinetic factors affecting local and systemic disposition of inhaled steroids Basic Clin Pharmacol Toxicol, 98 (2006), pp. 523-536 CrossrefView in ScopusGoogle Scholar 43 J.S. Patton, J.D. Brain, L.A. Davies, J. Fiegel, M. Gumbleton, K.J. Kim,...
Whether all inhaled corticosteroids at equivalent doses are associated with the same risk is unknown. Mechanisms of corticosteroid- induced bone changes The mechanism of corticosteroid-induced bone loss is complex. Adult bone matrix reflects a constant balance of activity between bone-forming osteoblasts...