An overview of the cellular and molecular immunopathology of asthma, highlighting the need and logic for the development of a novel, non-steroidal, small molecule drug for topical delivery targeting bronchial smooth muscle hyperresponsiveness and airways inflammation, particularly corticosteroid-refractory inf...
Medium-dose inhaled corticosteroid plus LABA best for pediatric uncontrolled asthma A medium inhaled corticosteroid dose plus a long-acting beta agonist was found to be the most beneficial step-up treatment option for children with uncontrolled asthma, according to a meta-analysis published in European...
ED, Emergency department; FP, fluticasone; ICS, inhaled corticosteroid; LABA, long-acting β2-agonist; LTRA, leukotriene receptor antagonist; OCS, oral corticosteroid; SABA, short-acting β2-agonist; TRACK, Test for Respiratory and Asthma Control in Kids. ∗Before stepping up therapy, confirm ...
Several covariates, such as prior asthma, malignancy, rheumatoid arthritis, Cushing's syndrome, hyperthyroidism, and use of systemic corticosteroids, were reported as potential confounders of osteoporosis and used as the exclusion criteria26. We use the proxy indicators to confirm COPD severity, includin...
Medications in bold indicate higher level subgroups of ICS and non-ICS containing medications Abbreviations: ICS Inhaled corticosteroid, LABA Long acting beta-agonist, LAMA Long acting muscarinic antagonist Study follow-up time Figure 2 illustrates change in FEV1 in ICS and non-ICS- containing ...
ICS: inhaled corticosteroid; SABA, short-acting β2-agonist. *Adjusted for baseline exacerbations (ATS/ERS Definition, categorized), evidence of GERD and baseline asthma prescriptions (categorized); †Adjusted for baseline Risk-domain asthma control, evidence of GERD and asthma diagnosis; ‡...
or increase in inhaled corticosteroid or other asthma medication 118 10 106 21 −11.3 (−20.7 to −2.2) 0.43 (0.21 to 0.87) Low Mild 118 74 106 77 −9.9 (−21.7 to 2.4) 0.86 (0.72 to 1.04) Low SMART vs Same Dose of Inhaled Corticosteroids and LABA as Controller Therapy Asthma...
(a) Use of short-acting 脦虏-agonist (SABA) rescue medication and (b) use of inhaled corticosteroid (ICS) maintenance medication during the different stages of an asthma worseningMartyn R PartridgeThys van der ...
However, the epidemic of asthma deaths which occurred in the 1960s led to these drugs being superseded by the selective short-acting beta-agonist salbutamol, and the first inhaled corticosteroid (ICS) beclomethasone. At the same time, sodium cromoglycate was introduced, to be administered via ...
(SABA alone), with or without bromide ipratropium and/or SC. The following outcomes were considered: clinical effects, use of systemic corticosteroid, hospital admissions and permanence in Accident and Emergency (A&E) unit. As for the second question, studies on the effectiveness of the up-dose...