Laboratory AbnormalityAll Grades (%)Grade 3–4 (%)All Grades (%)Grade 3–4 (%) Hypertriglyceridemia 63 0.4 53 0 High AST 31 2.1 36 1.5 Hypokalemia 28 5.3 20 1.0 Hypophosphatemia 24 7.2 16 5.8 High ALT 11 1.4 10 0.8 High Total Bilirubin 6.6 0.1 4.6 0 COU-AA-302: Metastatic CRPC ...
17.1 Increased Risk of High-Grade Prostate Cancer Patients should be informed that there was an increase in high-grade prostate cancer in men treated with 5α-reductase inhibitors indicated for BPH treatment, including finasteride, compared to those treated with placebo in studies looking at the use...
aboard the Space Station, talking directly to ham radio satellites in space that relay your signals to earth far beyond your horizon, or just around the block or around the world using your own licensed station and equipment!
Aristarchus’ revolutionary astronomical hypothesis was that the Sun, not the Earth, was the fixed centre of the 'universe' and that all the planets revolved around it. He also said the stars were distant unmoving suns and the universe was much larger than thought. Here his method is used ...
Imagine the thrill of talking to the astronauts, many of whom are licensed "ham radio operators", aboard the Space Station, talking directly to ham radio satellites in space that relay your signals to earth far beyond your horizon, or just around the block or around the world using your own...
Cognitive adverse reactions occurred in 28% of 148 patients with AdvSM who received AYVAKIT; 3% were Grade ≥ 3. Memory impairment occurred in 16% of patients; all events were Grade 1 or 2. Cognitive disorder occurred in 10% of patients; <1% of these events were Grade 3. Confusional sta...
Fistula, Grade 4 Fistula formation involving any internal organ Discontinue Avastin Wound Healing Complications [see Warnings and Precautions (5.2)]. Any Withhold AVASTIN until adequate wound healing.The safety of resumption of AVASTIN after resolution of wound healing complications has not been establis...
Adverse ReactionsAll Grades (%)Grade 3-4 (%) * Adverse drug reactions, graded using NCI-CTCAE v 4.0 (NCI common toxicity criteria) for assessment of toxicity. † Cases of cutaneous squamous cell carcinoma were required to be reported as Grade 3 per protocol. Skin and subcutaneous tissue...
f Grade 3 = 3+, large; Grade 4 = ≥4+, marked, severe, many.ULN=upper limit of normal. Any Grade 3–4 laboratory abnormalityd 35% 36% 37% 45% ALT >10 × ULN and >2 × baseline 2% 4% 2% 11% ALT >5 × ULN 11% 16% 12% 24% Albumin <2.5 g/dL <1% <1% 0...
In the NSABP P-1 trial, few grade 3 to 4 changes in liver function (SGOT, SGPT, bilirubin, alkaline phosphatase) were observed (10 on placebo and 6 on tamoxifen). Serum lipids were not systematically collected. Other Cancers A number of second primary tumors, occurring at sites other than...