The fate of influenza A virus (IAV) infection in the host cell depends on the balance between cellular defence mechanisms and viral evasion strategies. To illuminate the landscape of IAV cellular restriction, we generated and integrated global genetic loss-of-function screens with transcriptomics and...
Initial attachment of the virus to the host cell is mediated by the binding of terminal sialic acids (Sia) of glycoconjugates to HA. At the final step of the infectious cycle NA cleaves Sia to ensure virus release from the cell surface. In this overview focus will be given to the ...
Influenza virus articles from across Nature Portfolio Atom RSS Feed Influenza virus is an infectious agent belonging to the virus family Orthomyxoviridae that causes a respiratory tract infection (influenza or 'flu') in vertebrates. There are three main species, and of these, influenza A viruses ...
Hemagglutinin (HA) and neuraminidase (NA) are the two major surface proteins of influenza A virus (IAV). Initial attachment of the virus to the host cell is mediated by the binding of terminal sialic acids (Sia) of glycoconjugates to HA. At the final step of the infectious cycle NA ...
9.3.1Gene Therapy for Infection with Influenza Virus A Evidence indicates that the RNAi pathway serves as an antiviral mechanism of host cells against influenza virus A[39,40]. However, the virus may counter the antiviral effects of hostgene silencingthrough effects of theNS1 protein[41], a...
To summarize, TCM has a significant therapeutic effect on H1N1 influenza virus infection, with its mechanism of action being closely related to the regulation of intestinal flora. Fig. 1 After infecting the lungs, IAV can alter the composition and metabolism of the gut microbiota, leading to comp...
Influenza virus is a canonical example of an enveloped virus that has caused world-wide pandemics [11]. Because it inhabits multiple hosts and readily mutates, the threat of a new pandemic is real. The fusion of the viral and host cell membranes is mediated by hemagglutinin, a class I tri...
Picture of the influenza virus Influenza, commonly called "the flu," is an illness caused by RNA viruses (Orthomyxoviridae family) that infect the respiratory tract of many animals, birds, and humans. In most people, the infection results in the person getting a fever, cough, headache, and ...
Type III interferon (IFN-λ) is important for innate immune protection at mucosal surfaces and has therapeutic benefit against influenza A virus (IAV) infection. However, the mechanisms by which IFN-λ programs adaptive immune protection against IAV are undefined. Here we found that IFN-λ signali...
Despite the cytopathic nature of influenza A virus (IAV) replication, we recently reported that a subset of lung epithelial club cells is able to intrinsically clear the virus and survive infection. However, the mechanisms that drive cell survival during a normally lytic infection remained unclear....