is associated withStreptococcus pneumoniae,Staphylococcus aureus,Haemophilus influenzaeor group A β-hemolytic streptococci.S. pneumoniae,H. influenzaeandMoraxella catarrhalisare the pathogens often found in otitis media. Large influenza epidemics are associated with an increase in the overallmortality rate, ...
Influenza virus continues to cause seasonal epidemics and pandemics despite vaccine availability. In addition, highly pathogenic avian influenza viruses cause sporadic outbreaks in humans with a high mortality rate, posing potential risk of human adaptation and are considered pandemic threats1. Viral glycop...
The pregnancy outcomes were also poor for women who were affected by the virus with a fivefold increase in the perinatal mortality rate and threefold increase in the preterm delivery rate (Yates et al. Health Technol Assess 14(34):109-182, 2010). There continues to be a low uptake of ...
The former is of great importance in isolating new strains of the virus, which helps in the decision-making process concerning the composition of the vaccine, and the latter provides estimates of morbidity, mortality or economic impact as a result of infection from the influenza virus. Rapid ...
Influenza A virus (IAV) is one of the most common causes of acute severe respiratory diseases worldwide. IAV infections are associated with high morbidity and mortality rates and have substantial socioeconomic impact1,2. Rodent models are widely used to study human lung diseases; however, these ...
Influenza Infectious Dose May Explain the High Mortality of the Second and Third Wave of 1918–1919 Influenza Pandemic It is widely accepted that the shift in case-fatality rate between waves during the 1918 influenza pandemic was due to a genetic change in the virus. In an... AC Paulo,M ...
Results: We estimated that the influenza A(H1N1)pdm09 mortality rate per 100,000 person-years (py) ranged from 1.5 among persons aged 5-44 years to 5.6 among persons aged ≥65 years. A(H1N1)pdm09 hospitalization rates per 100,000 py ranged between 26.9 among children aged < 5 years to...
1f), indicating a moderate interaction but one that is within the range that has been reported to effectively neutralize the virus (KD < 250 nM) (Fig. 1f)17, while its relatively fast off rate might restrict its effectiveness and potency in some assays. Consistent with its ...
Across England, we were therefore able to examine how mortality rates varied by socio-economic group, between urban and rural areas, and between regions. Results People in the most deprived quintile of England's population had an age and sex-standardised mortality rate three times that experienced...
Even developed countries may not be able to withstand a rapidly spreading 1918-like influenza pandemic with a mortality rate of over 50%. Thus early intervention by quarantine of contacts, social distancing and rapid administration of a central stockpile of antiviral and vaccine to the targeted popu...