Lipid nanoparticles (LNPs) have emerged as the predominant delivery vehicle for RNA therapeutics. An important component of LNPs is the ionizable lipid (IL), which is protonated in the acidic environment of the endosome, prompting cargo release into the cytosol. Currently, there is growing ...
Hybrid is based on the separation of ionizable groups into clusters, where the interaction between ionizing charges within a cluster is treated exactly and intercluster interactions are approximated (Gilson, 1993). The atoms of the protein were assigned point charges and radii from the modified ...
the topical application of MB has certain challenges. MB is a cationic and water-soluble molecule. These properties limit its partition and diffusion through the layers of the skin, limiting it from reaching the neoplastic cells at therapeutic...
ReP1-NCXSQ acquired an orientation in the anionic membranes with the positive end of the macrodipole pointing to the lipid membrane. Potential of mean force calculations, in agreement with experimental measurements, showed that the binding to the anionic interfaces in low ionic strength was ...
The light-scattering data indicated that only a small fraction of the ionizable surface sites (phosphate) of the lipid A-diphosphate was partly dissociated (similar to 30%). It was also discovered that a given amount of Ca2+ (1.0-5.0 nM) or K+ (100 mu M) influenced the structure much...
The results were expressed in mg of tannic acid/100 g of dry matter. 2.1.5.2. Determination of proximate composition The proximate chemical composition of the different flours (moisture, protein, fiber, ash, lipid, carbohydrate contents, and energy value) was carried out according to the ...
Thus, enzymatic hydrolysis of the meals was carried out to increase their solubility, by releasing shorter peptides with more exposed ionizable groups. The hydrolysis reaction was conducted in a jacketed glass reactor of 1 L capacity. Firstly, a solution containing 2.5% of protein w/v was ...
Small intestine pH and buffer capacity: implications for dissolution of ionizable compounds... There are more references available in the full text version of this article. Cited by (42) Simulated, biorelevant, clinically relevant or physiologically relevant dissolution media: The hidden role of bicar...
Additionally, transport of ionizable drugs that are initially at high concentrations in liposomes can generate or dissipate pH gradients across the barrier causing deviations from classical pH-permeability profiles. In this study, the liposomal release of a model amine (tyramine) is determined as a ...
A lack of ionizable Ca may limit the attachment of bacteria to particles, thus reducing ruminal digestion. In contrast, variations of Mg from lipid supply were lower than those of Ca. The interaction between time and diet was significant for soluble and ionizable Ca contents of ruminal fluid....