inflammatory skin diseasesKeratinocytes, the predominant cell type in the epidermis, are indispensable for maintaining skin barrier integrity, mediating host defense, and orchestrating immune responses. Beyond
Influx of inflammatory cells in the nose was evaluated in 14 patients with rhinitis and 11 healthy subjects. Nasal secretions were obtained by nasal lavages. Total cell count and differential count were carried out with a Neubauer chamber and in cytospin slides, respectively. Cells were classified...
Hnrnpdtm1Rjs mice exhibit a enhance CHS response suggesting a greater susceptibility to hapten-specific T-cell-mediated skin inflammation, such as allergic contact dermatitis (Saint-Mezard et al., 2004). This report focuses on similarities between the pruritic inflammatory skin disease in Hnrnpdtm1...
Inflammatory bowel disease: classifying global regions by epidemiological stage Jordan Hindson Research Highlights13 May 2025Nature Reviews Gastroenterology & Hepatology Volume: 22, P: 369 Skin–gut crosstalk Nicholas J. Bernard Research Highlights30 Apr 2025Nature Immunology ...
Eighty-six participants (38.1%) of all IBD patients (52.5% of CD patients and 32.9% of UC patients) had skin disease at the time of examination. Patients with CD were significantly more likely to have skin disease at the time of examination or while IBD was active (p=0.008 andp=0.019,...
Inflammatory bowel diseaseExtraintestinalSkin lesionParadoxical reactionAnti-tumor necrosis factorInflammatory bowel disease (IBD) is associated with a number of extraintestinal complications, including skin lesions. Most reports have shown that skin lesions are found in 10–15% of IBD cases, although ...
(AGS). An inheritable neuroinflammatory disease that leads to microcephaly and intellectual disability with extraneurological vasculitic skin lesions. This condition is driven by chronic IFN signalling caused by mutations in genes involved in DNA degradation and metabolism or RNA editing and recognition. ...
Psoriasisis a chronic autoimmune inflammatory skin disease characterized by red, scaly, and raised plaques that are often observed on the skin as a result of increased inflammatory cell infiltrates in the epidermis and dermis, and increased keratinocyte proliferation and altered differentiation. Andrographo...
"We were surprised to discover that apoptosis was the culprit in the development of inflammatory skin disease, while more extensive, system-wide inflammation such as in the liver and spleen was driven by necroptosis," Mr Rickard said. "This was quite unexpected, because apoptosis is not normally...
Both nutritional excess and deficiency are associated with disease. For example, nutritional excess, particularly in refined carbohydrates and saturated fats, coupled with physical inactivity, can result in chronic inflammatory conditions such as obesity and cardiovascular disease. On the other hand, ...