Chronic inflammatory articular disorders are a major cause of disability, and appropriate study models remain a research challenge. Biomaterials are used to build in vitro models and are tested using in vitro, ex vivo, and in vivo models. Recent, advanced in vitro, ex vivo, and in vivo ...
while experiencing widespread and often severeinflammatory injury. However, this resilience comes at a cost, and a third principle is that chronic inflammatory disorders are often associated with an increased risk of neoplasia. There are numerous plausible molecular explanations for how chronic ...
Cytokines: inflammatory mediators of joint disease 来自 国家科技图书文献中心 喜欢 0 阅读量: 13 作者: JS Price,JA Symons,RGG Russell 展开 摘要: No abstract is available for this article. 展开 关键词: reponse immunitaire, cytokinins, facteur immunologique, INTERLEUKINS, factores inmunolog...
Molecular imaging with positron emission tomography (PET) and single-photon emission computed tomography (SPECT) is increasingly used to diagnose, characterize, and monitor disease activity in the setting of inflammatory disorders of known and unknown etiology. These disorders include sarcoidosis, atheroscle...
Inflammation and immunity dysregulation have received widespread attention in recent years due to their occurrence in the pathophysiology of many conditions. In this regard, several pharmacological studies have been conducted aiming to evaluate the potential anti-inflammatory and immunomodulatory effects of ph...
12. Any form of arthritis that affects one or more vertebral joints, spondylarthritis represents a group of closely related disorders, including ankylosing spondylitis, psoriatic arthritis, and arthritis associated with inflammatory bowel disease. ...
Consistently, genome-wide association studies recently identified key driver genes of macrophages for inflammatory disorders22. During the course of inflammation, however, monocyte-derived macrophages seem to acquire essential anti-inflammatory and pro-resolving functions23. They clear apoptotic cells, start...
Given that the functions of GM-CSF span multiple tissues and biological processes, this cytokine has shown potential as a new and important therapeutic target in several autoimmune and inflammatory disorders — particularly in rheumatoid arthritis. Indeed, GM-CSF was one of the first cytokines ...
A pharmaceutical composition which has an anti-inflammatory effect and inhibits the progressive damage to joints in mammals with arthritic disorders is provided. The composition contains as active ingredient specific 2,4,6-tris(alkylamino)-s-triazines of the formula I. The invention also relates to...
- For autoimmune disorders - Very potent anti-inflammatory - Used in RA when other agents haven't worked - Cause weakened immune system - Can't use in pts with active infection - Can cause liver + kidney toxicity: monitor - Bone marrow suppression: check CBC ...