disease.3 RANKL may also increase the lifespan and activity of dendritic cells (DCs), which accumulate in the colon in colitis.3 We hypothesise that the RANKL pathway links the development of colitis with bone disease and aimed to determine the mechanism of action of RANKL, OPG and TSG6 on...
The exact mechanism of cellular dysfunction leading to IBD is not fully understood. However, modulating the function of immune cells could be a powerful tool in the treatment of inflammatory diseases. The adaptation of T lymphocytes to the intestinal environment requires constant differentiation between ...
Sophie Hambleton, Professor of Pediatrics and Immunology at Newcastle University, and honorary consultant pediatrician at Newcastle upon Tyne Hospitals NHS Foundation Trust, said, "Here, we drew upon knowledge of genetic forms of IBD to uncover a new and unexpected molecular mechanism for disease. "T...
Unravelling of nitric oxide signalling: A potential biomarker with multifaceted complex mechanism associated with canine inflammatory bowel disease (IBD) Tanmoy Rana, in Anaerobe, 2020 Abstract Inflammatory bowel disease (IBD) is an important chronic condition associated with the infection affecting the gas...
Conclusion IBD is more common in type 1 diabetes than the general population although the mechanism is uncertain but may be related to autoimmunity. Quality of life is adversely affected by having both IBD and type 1 diabetes but this could not be explained by changes in glycaemic control. inf...
The mechanism involves the competition of the PPI and clopidogrel with the same cytochrome P450 (CYP2C19). Whether this is a class effect of PPIs is unclear; there appears to be at least a theoretical advantage of pantoprazole over the other PPIs, but this has not been confirmed. This drug ...
Inflammatory bowel disease: past, present, and future Accumulating data from animal models indicate that Inflammatory bowel disease (IBD) is mediated by a much more complicated mechanism than previously predi... A Mizoguchi,E Mizoguchi - 《Journal of Gastroenterology》 被引量: 1636发表: 2008年 Tow...
These studies have shown that the predominant mechanism of diarrhea in IBD involves impairment of electroneutral NaCl absorption, with very little role if any played by anion secretion. The electroneutral NaCl absorption involves coupled operation of Na/H exchanger 3 (NHE3 or SLC9A3) and Cl/HCO3...
Curtin Health Innovation Research Institute, Biosciences Research Precinct, School of Pharmacy, Curtin University, Perth, WA, Australia Abstract: Inflammatory bowel disease (IBD) is defined as a chronic intestinal inflammation that results from host-microbial interactions in a genetically susceptible individu...
Potential viral pathogenic mechanism for new variant inflammatory bowel disease Aims: A new form of inflammatory bowel disease (ileocolonic lymphonodular hyperplasia) has been described in a cohort of children with developmental disord... LM Wakefield,L Pilkington,IMC Martin,... - 《Child Care ...