Scientists discover how gut modulates development of inflammatory conditions A study led by David Sancho at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid reveals how an increase in intestinal permeability allows the natural gut bacteria to cross the intestinal barrier and ......
Review article: mode of action and delivery of 5-aminosalicylic acid — new evidence. Aliment. Pharmacol. Ther. 24, 2–9 (2006). PubMed CAS Google Scholar Słoka, J., Madej, M. & Strzalka-Mrozik, B. Molecular mechanisms of the antitumor effects of mesalazine and its preventive ...
[61]. Autocrine action is the interaction of cytokines on the cells that secrete them, while paracrine action is the interaction on nearby cells, and endocrine action is the interaction on distant cells. Some of these cytokines act to make the disease worse (proinflammatory), whereas others ...
Hyperglycemia induces skin barrier dysfunctions with impairment of epidermal integrity in non-wounded skin of type 1 diabetic mice. PLoS ONE. 2016;11:e0166215. Article PubMed PubMed Central Google Scholar Lee J, Jang H, Park S, Myung H, Kim K, Kim H, Jang W-S, Lee S-J, Myung JK...
The mode of action of exogenous MANF remains unclear, but immunomodulatory effects have been suggested as a putative mechanism for MANF’s cytoprotective properties. Administration of recombinant MANF into mouse brain has been shown to downregulate inflammation by decreasing NF-κB-mediated pro-...
Chronic non-communicable diseases (CNCDs) pose a significant public health challenge. Addressing this issue, there has been a notable breakthrough in the prevention and mitigation of NCDs through the use of antioxidants and anti-inflammatory agents. In t
However, the action of u-QUE on macrophages was dependent on the previous inflammatory activation state of these cells. In non-activated macrophages, u-QUE triggered a consistent inflammatory response and increased the cell proliferation rate, with a monolayer showing spindle-like and scattered macroph...
44. Bonavera JJ, Kalra SP, Kalra PS: Mode of action of interleukin-1 in suppression of pituitary LH release in castrated male rats. Brain Res 1993, 612:1-8. 45. Rivier C, Vale W: In the rat, interleukin-1 alpha acts at the level of the brain and the gonads to interfere with ...
In addition to this direct anti-oxidant properties, luteolin was also reported to inhibit LPS-induced activation of NF-κB and MAPK pathways, but its mode of action was not understood27. Luteolin is blood-brain barrier permeable and was reported to have a neuroprotective effect in drug-induced ...
(ii) mechanisms that promote the development of autoimmunity (e.g., citrullinated protein antibodies in arthritis), and (iii) processes leading to impairment of the barrier function of epithelial surfaces leading to prolonged microbial exposure (e.g., defensin and mucin reduction in inflammatory ...