Mice overexpressing Has2 from the naked mole-rat showed an increase in hyaluronan levels in several tissues, and a lower incidence of spontaneous and induced cancer, attenuated inflammation through several pathways, extended lifespan and improved healthspan. Zhihui Zhang , Xiao Tian & Vera Gorbunova ...
Chung, then working with mentor Charles Rice at Rockefeller University, discovered that ADAR1-mediated modifications made to our own double-stranded RNA molecules keep pattern recognition receptors from constantly triggering inflammation in healthy tissues. The team reportedtheir findingsinCellin 2018. That...
inflammation; synthetic anti-inflammatory agents; natural anti-inflammatory agents; mechanisms of action; in vitro and in vivo anti-inflammatory assays 1. Introduction Inflammation is a defense mechanism designed to eradicate microbes or irritants, thus protecting living tissues from infection injuries and...
The spatiotemporal regulation of immune cells in lymph nodes (LNs) is crucial for mounting protective T-cell responses, which are orchestrated by dendritic cells (DCs). However, it is unclear how the DC subsets are altered by the inflammatory milieu of L
body’s own tissues by its inability to differentiate between some of the body’s proteins and foreign invaders. In essence, the immune system wages war, against itself. Diseases such as rheumatoid arthritis and lupus erythematosus are the result. Clearly, inflammation can be a double-edged ...
Inflammation is a process by which tissues respond to various insults. It is characterized by upregulation of chemokines, cytokines, and pattern recognition receptors that sense microbes and tissue breakdown products. During pregnancy, the balance of Th1 (cell-mediated immunity) and Th2 (humoral immu...
Central nervous insulin resistance: a promising target in the treatment of metabolic and cognitive disorders? Research on functions and signalling pathways of insulin has traditionally focused on peripheral tissues such as muscle, fat and liver, while the brain was... M Hallschmid,B Schultes - 《...
(infection of the breast), hematomas (rupture of tiny blood vessels), fat necrosis (trauma to the fat cells in breast tissues), cysts (tiny [...] shanghai.ufh.com.cn 除了乳腺癌,乳腺炎(乳 腺感染)、血肿 (微 小 血管 破 裂) 、脂 肪坏死(乳腺组织的脂肪细胞损伤)、囊肿(乳腺组织内...
the interaction of tissues such as cartilage and synovium. The signaling pathways and corresponding molecular products involved in these processes offer potential targets for the treatment of OA, enabling the use of gene-editing therapies, especially with the CRISPR-Cas system, as potential tools for...
Collectively, PQBP1 is an intracellular receptor in the cGAS-STING pathway not only for cDNA of human immunodeficiency virus (HIV) but also for the transmissible neurodegenerative disease protein tau. This study characterises a mechanism of brain inflammation that is common to virus infection and ...