Compared with healthy control group mice, the spleen index of mice treated by DXM + GM enema at 2 weeks was reduced in response to radiation (Fig. 2B, ***P < 0.001). Therefore, long-term use of the DXM + GM enema may affect the role of the spleen in immunity. Figure...
Ustekinumab effectively reduces clinical symptoms and active inflammation detected by magnetic resonance imaging in patients with active ankylosing spondylitis: results of a 28-week, prospective, open-label, proof-of-concept study (TOPAS)rupture of the spleen...
AIM: To investigate the damage and effect of condition reflection box stress on the airway endothelial cells in mice with asthma as well as the regular changes in apoptosis of airway endothelial cells and its correlation with airway inflammation, and probe into the possible mechanism in the treatme...
Clear signal can be seen in the spleen (asterisk). See Supplementary Videos 36 and 38. b, Four (M1-M4) of five mice developed one or more symptoms of GVHD by day 112, at which point CD45-PET imaging was repeated. c, Repeat day 112 imaging show decreased spleen signal (asterisk) ...
There is a higher radia- tion dose to the spleen from 500 μCi of 111In WBC but radiation doses to gonads, marrow, and the whole body are higher with 5 mCi of 67Ga. 99mTc HMPAO-labeled WBCs could provide fast diagnosis and localization of the abdomen (within 2–4 h). Physiological...
(PTX). This model was induced according to the protocol [13]. The clinical symptoms of EAE and body weight were estimated daily, until day 21. The clinical EAE score was categorized as follows: [14]. The mice were sacrificed at day 22, and then the spleen, brain, and lumbar spinal ...
We found that postbiotic intervention effectively mitigated the symptoms and inflammation in colitis rats, evidenced by the improved spleen index, less severe colon tissue damage, and changes in serum cytokine levels (decreases in tumor necrosis factor-alpha and interleukin-1 beta; increase in ...
Inflammation is an essential pillar of the immune defense. On the other hand, chronic inflammation is considered a hallmark of cancer initiation and progre
Since downregulation of Treg cell differentiation is associated with the pathogenesis of OA, KGN may also reduce OA severity by the promotion of Treg cell differentiation and IL-10 production. The degeneration of cartilage is associated with primary clinical symptoms in the OA joint. It is well ...
Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of continuous cell expansion until the cytomembrane ruptures, resulting in the release of cellular contents that can activate strong inflammatory and immune responses. P