This technique, termed anti-LYVE-1 immuno-PET, was found to be very sensitive in the detection of metastasis to the lymph nodes. However, lymphatic vessel expansion to the lymph nodes can also be induced by inflammation, and it is currently unclear whether such vessel expansion is reversed ...
32 Further, in hypercholesterolemia, dendritic cell migration to lymph nodes is impaired.33 These reports highlight the importance of dendritic cells as mediators in atherogenesis and propagation of inflammation. The role of the innate immune system in atherosclerosis and CVD has been recently reviewed...
The spatiotemporal regulation of immune cells in lymph nodes (LNs) is crucial for mounting protective T-cell responses, which are orchestrated by dendritic cells (DCs). However, it is unclear how the DC subsets are altered by the inflammatory milieu of LNs. Here, we show that the inflamed ...
The spatiotemporal regulation of immune cells in lymph nodes (LNs) is crucial for mounting protective T-cell responses, which are orchestrated by dendritic cells (DCs). However, it is unclear how the DC subsets are altered by the inflammatory milieu of LNs. Here, we show that the inflamed ...
The role of innate lymphoid cells (ILCs) in immune homeostasis and disease is reviewed. A previously unappreciated cell type of the innate immune system, termed innate lymphoid cells (ILCs), has been characterized in mice and humans and found to influenc
The predominant Treg population residing in the lymphoid tissues is developed during the normal process of T cell maturation in the thymus, and thus is termed thymus-derived Treg (tTreg) or "natural Treg" (nTreg). In addition, a smaller but antigen-specific population that is induced in the...
This pro-inflammatory factor was shown to be elaborated by cell suspensions derived from lymph nodes of rats, rabbits, pigs or calves as well as from human tonsils. Thymus cells showed no such activity. The pro-inflammatory factor was termed as anaphylactoid-inflammation-promoting factor (AIPF)....
In mammals, the initial response to invading pathogens is mounted by the innate immune system. Immune cells such as macrophages, neutrophils and dendritic cells express receptors on their cell surface that recognize a range pathogen components collectively termed pathogen-associated molecular patterns (PAM...
An additional key component of inflammatory activation is a multimeric protein complex termed “inflammasome,” which is activated by cell nutrients, such as glucose and free fatty acids, inducing interleukin-1 beta (IL-1β) production (Böni-Schnetzler et al., 2009; Maedler et al., 2002)....
The total number of ILCregs was calculated and is shown as the mean ± SD. sLP, small intestine lamina propria; sIE, small intestine intra-epithelial cells; cLP, colon lamina propria; mLN, mesenteric lymph nodes; PP, Peyer’s patches; BM, bone marrow. (Lin = CD3e, CD4, CD8, CD19,...