Blumberg, published in the journal "Nature" showed that deletion of CD1 (cluster of differentiation 1) in intestinal epithelial cells (IECs) in colitis' invariant natural killer (iNKT) cells dependent model increases mortality.doi:10.1038/nm.3573Da Silva...
Leakage that occurs as a result of damage to the intestinal lining, which makes the internal environment of the gut leak out of the intestines into the bloodstream, triggering an immune response. Fenton reaction A reaction in which iron acts as a catalyst and reacts with hydrogen peroxide to ...
What is intestinal mucosa? What structure separates the colon from the small intestine? What organ system does the intestines belong to? What organ is at the end of the digestive tract? What causes a hole in the intestines? What body cavity is the large intestine in?
In CA-CRC, the innate immune system is activated in response to harmful microorganisms and damage to the intestinal lining [75]. This response involves pattern recognition receptors (PRRs), which detect microbial components or tissue damage, triggering immune signaling pathways that contribute to chron...
The new study led by researchers at the University of Wisconsin-Madison showed that yogurt can reduce inflammation by improving the integrity of the intestinal lining, thus preventing endotoxins, the pro-inflammatory molecules produced by gut microbes, from crossing into the blood stream. ...
The intestine is subjected to a barrage of insults from food, bacterial flora, and pathogens. Despite this constant antigenic challenge, the mucosal tissues lining the intestinal tract remain largely under control. The mechanisms regulating the homeostatic balance in the gut have been investigated for...
2. Master regulators of the UPR 3. Proteolytic degradation of target proteins by selective autophagy and interplay with intestinal inflammation 4. Crosstalk between autophagy and the proteasome: role for immune signaling 5. Pathways converging: autophagy and ER stress meet in intestinal inflammation 6....
Ulcerative colitis and intestinal inflammation Ulcerative colitis (UC) is an inflammatory bowel disorder that causes ulcers and inflammation in the gastrointestinal tract. UC occurs when the colon or/and rectum lining becomes inflamed. Genetic predisposition, dysregulated immune responses, defects in epithel...
Although this response is not a typical allergic reaction, the irritation of the intestinal lining by the presence of this food may create a situation wherein the protective tight junctions between the cells in the gut are opened up exposing the immune system to these compounds. This then leads...
Inflammatory bowel disease (IBD) is an idiopathic disease, probably involving an immune reaction of the body to its own intestinal tract. The two major types of IBD are ulcerative colitis (UC) and Crohn’s disease (CD). Crohn’s disease is also referred to as regional enteritis, terminal il...