Doctors at the North Shore-LIJ Health System have discovered that increased inflammation in the prostate may predict reduced risk for prostate cancer. The findings are published online in Cancer. Prostate cancer is one of the most common cancers in men, with an estimated 240,000 new cases ...
Inflammation in prostate carcinogenesis. Nature Reviews Cancer, 7 (4), 256–269. CentralDe Marzo AM, Platz EA, Sutcliffe S, Xu J, Gronberg H, Drake CG et al (2007) Inflammation in prostate carcinogenesis. Nat Rev Cancer 7(4):256–269 Central...
E-cadherin immunostaining was inversely associated with age and inflammation, while stromal COX-2 immunostaining was positively associated with age and inflammation in the prostate. These findings suggest that the prostate epithelial barrier is altered and inflammation is increased with age in the ...
In the United States and in “Westernized” countries, the prevalence of both prostate cancer and prostate inflammation is very high, indicating that the two pathologies could be causally related. Indeed, chronic inflammation is now regarded as an “enabling” characteristic of human cancer. Prostate...
5381 Among genetic alterations frequently found in human prostate cancers, PTEN loss of function is strongly implicated in prostate cancer development. We have created a murine model of prostate cancer by deleting the Pten tumor suppressor gene using the Cre-Loxp system. Our recent studies provide ...
Objectives: To investigate associations of chronic inflammatory infiltrate (CII) with prostate cancer (PCa) risk and the number of positive cores in patients elected to a first set of biopsies. Materials and methods: Excluding criteria were as follows: active surveillance, prostate specific antigen (...
Prostate is an immune-competent organ normally populated by inflammatory cells. Prostatic inflammation origincan be multi-factorial and there are some emerging evidences on its possible role as a factor involved in prostatecancer (PC) pathogenesis and progression.This review critically analyzes the role...
The findings of enavatuzumab-induced chemokines warrant further evaluation in clinical studies as potential biomarkers for such activity. The paper by M. Janiczek et al. presents a systematic review on immunotherapy as a promising treatment for prostate cancer. The authors summarize the recent ...
However, the origins of DNA breaks that underlie gene fusion formation in prostate cancers are far from clear. We demonstrate a role for inflammation-induced oxidative stress in the formation of DNA breaks leading to recurrent TMPRSS2-ERG gene fusions. The transcriptional status and epigenetic ...
RANK ligand, produced by inflammatory cells that invade advanced prostate tumors, triggers a chain reaction in which IKKα is activated, allowing it to enter the nucleus of the cancer cell, repressing Maspin. IKKα is a key linchpin in the pathway that turns off the Maspin gene and activates...