For example the symptoms of IBD are often unspecific, and diagnosis may be delayed with devastating impact on disease progression as a result [25]. Therefore, fast and reliable diagnostic tools are wanted [26]. During UC inflammation both the mucosa and submucosa will be affected, resulting in...
(c) Representative FACS plots showing differences in intracellular IL-17 and IL-22 between regions of the large intestine that are considered normal, with inactive colitis, or active colitis based on histopathology from UC patients. (d) Scatterplots summarizing the percentages of CD4 þ cells ...
Symptoms of IBD include severe diarrhoea, hematochezia, pain, fatigue and weight loss and the prolonged gastrointestinal inflammation associated with IBD can lead to debilitating and sometimes fatal complications including toxic megacolon, intestinal blockage, bowel perforation and malignancy. Extraintestinal ...