Verprolins have important roles in signaling to actin dynam- ics which were mainly mediated by the WASP proteins, and influence the actin polymerisation machinery inde- pendent on the WASP proteins19. In yeast, Vrp1 displays a subcellular distribution polarized towards sites of surface growth and ...
ActA mimics the ARP2/3 nucleation-promoting factor N-WASP. It binds to actin monomers and activates ARP2/3, thus promoting actin nucleation [64,65]. IcsA from Shigella recruits N-WASP and ARP2/3 on its surface to induce actin polymerization [66,67,68]. Rickettsia parkeri utilizes two ...
This initiation of EGFR signalling upregulates the cytoskeletal regulator protein N-WASP, which, in concert with paxillin, is upregulated as a result of integrin signalling, not only driving the effective internalisation and trafficking of the virus, but also increasing the motility of the infected ...